| 李华山,李华宏,唐宗江,张森,高枫,李国栋,王彩秀.肠癌康复汤对大肠癌患者术后免疫功能的影响[J].,2000,(8):580-582 |
| 肠癌康复汤对大肠癌患者术后免疫功能的影响 |
| Effect of Chang′ai Kangfu Decoction on Immunity in Postoperational Patients with Large Intestine Cancer |
| |
| DOI： |
| 中文关键词: 肠癌康复汤 大肠癌 免疫 |
| 英文关键词:Chang′ai Kangfu decoction large intestine cancer immunity |
| 基金项目: |
| Author Name | Affiliation | | 李华山 | LI Huashan, LI Huahong, TANG Zongjiang, et al Anorectal Department, Guang′ anmen Hospital, China Academy of Traditional Chinese Medicine, Beijing (100053 | | 李华宏 | LI Huashan, LI Huahong, TANG Zongjiang, et al Anorectal Department, Guang′ anmen Hospital, China Academy of Traditional Chinese Medicine, Beijing (100053 | | 唐宗江 | LI Huashan, LI Huahong, TANG Zongjiang, et al Anorectal Department, Guang′ anmen Hospital, China Academy of Traditional Chinese Medicine, Beijing (100053 | | 张森 | LI Huashan, LI Huahong, TANG Zongjiang, et al Anorectal Department, Guang′ anmen Hospital, China Academy of Traditional Chinese Medicine, Beijing (100053 | | 高枫 | LI Huashan, LI Huahong, TANG Zongjiang, et al Anorectal Department, Guang′ anmen Hospital, China Academy of Traditional Chinese Medicine, Beijing (100053 | | 李国栋 | LI Huashan, LI Huahong, TANG Zongjiang, et al Anorectal Department, Guang′ anmen Hospital, China Academy of Traditional Chinese Medicine, Beijing (100053 | | 王彩秀 | LI Huashan, LI Huahong, TANG Zongjiang, et al Anorectal Department, Guang′ anmen Hospital, China Academy of Traditional Chinese Medicine, Beijing (100053 |
|
| Hits: 1296 |
| Download times: 990 |
| 中文摘要: |
| 目的 :探讨肠癌康复汤对大肠癌患者术后免疫功能的影响。方法 :将 4 8例Dukes′B、C期的大肠癌手术后患者随机分为中药组 16例、化疗组 17例、中药加化疗组 (以下简称中化组 ) 15例 ,分别予服肠癌康复汤与 5 氟脲嘧啶 (5 FU)、丝裂霉素 (MMC)化疗 ,观察T淋巴细胞亚群、NK细胞及免疫球蛋白的动态变化并与健康人组作对比研究。结果 :手术前各组大肠癌患者的CD3+ 、CD4 + 及CD4 + /CD8+ 均明显下降 ,而CD8+ 明显增加 ,NK细胞活性亦明显低于健康人 (P <0 0 1) ,说明大肠癌患者的细胞免疫处于抑制状态。手术后 1周进一步下降 ,尤其是CD3+ 下降最为明显。而手术后 1个月 ,CD3+ 、CD4 + 及NK细胞活性在中药组首先恢复正常 ,术后 2个月中化组亦逐渐恢复正常 ,且这两组较治疗前均有不同程度的提高 ,但化疗组恢复较为缓慢。在体液免疫方面亦取得了相类似的结果。结论 :肠癌康复汤可显著提高大肠癌手术后患者的免疫功能。 |
| 英文摘要: |
| To explore the effect of Chinese drug Chang′ai Kangfu decoction (CAKF) on immunity in postoperational patients with large intestine cancer (LIC). Methods: Forty eight patients with LIC in Dukes′ B, C stage after operation were randomly assigned to 3 groups, the CAKF group (16 cases), chemotherapy group (17 cases) and combination therapy (CAKF plus chemotherapy) group (15 cases). 5 FU and mitomycin C were given to the chemotherapy group. The dynamic changes of T lymphocyte subsets, NK cells and immunoglobulins were investigated. Results: Before operation, the CD 3 +, CD 4 +, CD 4 +/CD 8 + and the activity of NK cells in LIC patients were lower, but CD 8 + was higher than that of normal level (P<0 01), which indicated that cellular immunity in LIC was in immunosuppresive state, they all further reduced 1 week after operation, particularly CD 3 + cell counts, but CD 3 +, CD 4 + and the activity of NK cells normalized 1 month after operation in CAKF group,and 2 months were needed to normalize in combination therapy group. Both groups recovered to a certain extent in comparing with before treatment, but the chemotherapy group recovered slower. The similar results appeared in humoral immunity. Conclusion: CAKF could obviously increase the immunity in LIC patients after operation. |
| View Full Text View/Add Comment Download reader |
|
|
|
