| 任平,黄熙,张莉,王骊丽,刘芳,李月彩.四君子汤对实验性脾虚大鼠胃排空率的影响[J].,2000,(8):596-598 |
| 四君子汤对实验性脾虚大鼠胃排空率的影响 |
| Effect of Sijunzi Decoction on Gastric Emptying Rate in Rat Model of Spleen Deficiency Syndrome |
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| DOI： |
| 中文关键词: 四君子汤 脾虚证 动物模型 胃排空 脑-肠肽 胃肠电活动 |
| 英文关键词:Sijunzi decoction Spleen Deficiency Syndrome animal model gastric emptying rate brain gut peptide gastroduodenal myoelectrical activity |
| 基金项目:国家自然科学基金!资助项目 (No .39670 865 ;39770 886) |
| Author Name | Affiliation | | 任平 | REN Ping, HUANG Xi, ZHANG Li, et al. Xijing Hospital, the Fourth Military Medical University, Xi′an (710032 | | 黄熙 | REN Ping, HUANG Xi, ZHANG Li, et al. Xijing Hospital, the Fourth Military Medical University, Xi′an (710032 | | 张莉 | REN Ping, HUANG Xi, ZHANG Li, et al. Xijing Hospital, the Fourth Military Medical University, Xi′an (710032 | | 王骊丽 | REN Ping, HUANG Xi, ZHANG Li, et al. Xijing Hospital, the Fourth Military Medical University, Xi′an (710032 | | 刘芳 | REN Ping, HUANG Xi, ZHANG Li, et al. Xijing Hospital, the Fourth Military Medical University, Xi′an (710032 | | 李月彩 | REN Ping, HUANG Xi, ZHANG Li, et al. Xijing Hospital, the Fourth Military Medical University, Xi′an (710032 |
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| 中文摘要: |
| 目的 :观察四君子汤对实验性脾虚大鼠胃排空作用的影响 ,并从胃、十二指肠肌电及脑 肠肽浓度方面探讨四君子汤健脾益气的作用机制。方法 :用利血平制作实验性脾虚大鼠模型 14天后 ,大鼠随机分为 :A组 (四君子汤治疗 )、B组 (六味地黄汤治疗 )、C组 (自然恢复 )、D组 (脾虚模型 ) ,持续 14天 ;并与E组 (正常对照 )对照。处理 14天后 ,用同位素检测其胃液体排空功能 ,用双极银丝电极观察胃窦、十二指肠电活动 ,用放射免疫分析法 (RIA)测定下丘脑和血浆中胃动素 (MOT)、胆囊收缩素 (CCK)及生长抑素 (SS)的浓度。结果 :与正常对照组比较 ,脾虚模型大鼠胃排空率下降 ;MOT和SS在下丘脑及血浆中的水平下降、CCK水平升高 ;胃电慢波节律、振幅及运动指数均下降 (P <0 0 1,P <0 0 5)。经四君子汤治疗后上述各值均恢复正常 ,与正常对照组比较无统计学差异。而经六味地黄汤治疗及自然恢复的大鼠 ,仅胃和十二指肠电慢波活动有一定改善 ,但与四君子汤治疗组比较仍有显著性差异 (P <0 0 1,P <0 0 5)。结论 :四君子汤能促进脾虚大鼠胃液体排空 ,其机制可能与其调整下丘脑及血浆中MOT、CCK和SS的水平 ,调整胃、十二指肠肌电活动有关。 |
| 英文摘要: |
| To observe the effect of Sijunzi decoction (SJZ) on gastric emptying rate in rat model of Spleen Deficiency Syndrome (SDS) and to explore the mechanism of “Yiqi Jianpi” (replenishing Qi and invigorating Spleen) effect with gastroduodenal myoelectrical activity and brain gut peptide concentration. Methods: After intramuscular injection of reserpine for 14 days, the rat model of SDS was established. Rats were randomly divided into 5 groups, group A treated by SJZ, group B treated by Liuwei Dihuang decoction (LWDH), group C naturally recovered, group D SDS rat model, consecutively treated for 14 days, and compared with group E, the normal control. Using radioisotopic technique to monitor 30 min gastric liquid emptying rate, and using the implanted bipolar silver electrode to observe the antral and duodenal myoelectrical slow wave, and the plasma and hypothalamus levels of motilium (MOT), cholecystokinin (CCK) and somatostatin (SS) were measured by radioimmunoassay (RIA) 14 days later respectively. Results: Compared with the nomal control, gastric liquid emptying rate of rat SDS model was lowered (P<0 01, P<0 05); the hypothalamus and plasma levels of MOT and SS reduced, both hypothalamus and plasma had higher CCK levels (P<0 01, P<0.05); in comparing with the controls, the rhythm, amplitude and motility index of myogastric slow wave were lower also. After treated with SJZ, the aforesaid data were normalized with insignificant difference in comparing with the nomal control (P<0 01), but the rat SDS model treated by LWDH and in natural recovery had no significant improvement. Conclusion: SJZ can promote gastric liquid emptying rate of rat SDS model by improving the myogastric electrical movement as well as regulating the levels of MOT, CCK and SS. |
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