| 徐立然,华琼,王琳,蒋士卿.蝉贝咳喘平治疗支气管哮喘的临床与实验研究[J].,2000,(9):649-652 |
| 蝉贝咳喘平治疗支气管哮喘的临床与实验研究 |
| Clinical and Experimental Study on Effect of Chanbei Kechuanping in Treating Bronchial Asthma |
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| DOI： |
| 中文关键词: 蝉贝咳喘平 哮喘 淋巴细胞功能亚群 血栓素B2 6-酮-前列腺素F1α 肺功能 |
| 英文关键词:Chanbei Kechuanping asthma lymphocyte subsets thromboxane B 2 6-keto-prostaglandin F 1α pulmonary function |
| 基金项目: |
| Author Name | Affiliation | | 徐立然 | XU Liran, HUA Qiong, WANG Lin, et al Henan Academy of TCM, Zhengzhou (450004 | | 华琼 | XU Liran, HUA Qiong, WANG Lin, et al Henan Academy of TCM, Zhengzhou (450004 | | 王琳 | XU Liran, HUA Qiong, WANG Lin, et al Henan Academy of TCM, Zhengzhou (450004 | | 蒋士卿 | XU Liran, HUA Qiong, WANG Lin, et al Henan Academy of TCM, Zhengzhou (450004 |
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| 中文摘要: |
| 目的 :观察蝉贝咳喘平治疗支气管哮喘的临床疗效 ,并探讨其机制。方法 :将 96例哮喘患者随机分为蝉贝咳喘平治疗组 (治疗组 )和桂龙咳喘宁对照组 (对照组 )。观察治疗前后哮喘症状及体征、肺功能、T淋巴细胞功能亚群、可溶性白介素 2受体 (sIL 2R)、血浆血栓素B2 (TXB2 )及 6-酮 -前列腺素F1α( 6 keto PGF1α)等的变化。实验研究观察了对豚鼠哮喘的影响。结果 :( 1)治疗组临床控显率和有效率均高于对照组 ;治疗组和对照组对肺功能 1秒钟用力呼气容积 (FEV1 0 )、最大呼气流速 (PEFR)及用力呼气肺活量 (FVC)均有改善作用 ,但治疗组作用更明显。 ( 2 )与对照组比较 ,治疗组sIL 2R、T淋巴细胞功能亚群均显著降低 ,6 keto PGF1α升高。蝉贝咳喘平对豚鼠哮喘的影响结果显示 :与模型组比较 ,治疗组能明显延长引喘潜伏期、明显降低肺泡灌洗液 (BALF)中细胞总数和肥大细胞比例、降低血液嗜酸细胞数和肥大细胞脱颗粒率、降低血清免疫球蛋白E(IgE)、白细胞介素 4 (IL 4 )及TXB2 ,升高 6 keto PGF1α。结论 :蝉贝咳喘平对哮喘发作的治疗有较好疗效。可能部分通过调节T淋巴细胞功能亚群、减少血清IgE、sIL 2R、IL 4及减少TXB2 、升高 6 keto PGF1α而起作用。 |
| 英文摘要: |
| To observe the clinical effect of Chanbei Kechuanping (CBKCP) on bronchial asthma and to explore its mechanism. Methods: Ninety-six patients of bronchial asthma were randomly divided into two groups, the CBKCP treated group and the control group (treated by Guilong Kechuanning). The changes on symptoms and signs of asthma, pulmonary function, T-lymphocyte subsets, plasma soluble interleukin-2 receptor (sIL-2R), thromboxane B 2 (TXB 2) and 6-keto-prostaglandin F 1α (6-keto-PGF 1α ) were observed before and after treatment. Results: (1) The markedly effective rate and effective rate in the CBKCP treated group were higher than those in the control group. The pulmonary function, including 1 second forced expiratory volume, maximum expiratory flow rate and forced lung expiratory vital capacity were all improved in both groups, but the effect was more obvious in the CBKCP treated group. (2) As compared with the control group, CBKCP showed more obvious effect in lowering sIL-2R, T-lymphocyte subset and raising 6-keto-PGF 1α . Experimental study of guinea pig with asthma model showed that CBKCP could markedly prolong the latent time of asthma attack, lower the percentage of mast cells in total cells in the alveoli lavage solution, blood acidophic cell count and degranulation rate of mast cells, and decrease IgE, IL-4 and TXB 2 levels as well as increase the 6-keto-PGF 1α level. Conclusion: CBKCP has favorable therapeutic effect on asthma attack, it might play the role partly by regulating the functional T-lymphocyte subsets, reducing the level of IgE, sIL-2R, IL-4 and TXB 2, and increasing the level of 6-keto-PGF 1α . |
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