| 孙延兵,陈秉良,贾强,姚峥.新清宁配合小剂量持续胃肠透析治疗尿毒症临床疗效观察[J].,2000,(9):660-663 |
| 新清宁配合小剂量持续胃肠透析治疗尿毒症临床疗效观察 |
| Clinical Effect of Xinqingning Combined Low Dose Continuous Gastrointestinal Dialysis in Treating Uremia |
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| DOI： |
| 中文关键词: 慢性肾功能衰竭 尿毒症 持续胃肠透析 大黄 甘露醇 |
| 英文关键词:chronic renal failure uremia continuous gastrointestinal dialysis rhubarb mannitol |
| 基金项目: |
| Author Name | Affiliation | | 孙延兵 | SUN Yanbing, CHEN Bingliang, JIA Qiang, et al Department of Nephrology, Xuanwu Hospital, The Capital University of Medical Sciences, Beijing (100053 | | 陈秉良 | SUN Yanbing, CHEN Bingliang, JIA Qiang, et al Department of Nephrology, Xuanwu Hospital, The Capital University of Medical Sciences, Beijing (100053 | | 贾强 | SUN Yanbing, CHEN Bingliang, JIA Qiang, et al Department of Nephrology, Xuanwu Hospital, The Capital University of Medical Sciences, Beijing (100053 | | 姚峥 | SUN Yanbing, CHEN Bingliang, JIA Qiang, et al Department of Nephrology, Xuanwu Hospital, The Capital University of Medical Sciences, Beijing (100053 |
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| 中文摘要: |
| 目的 :观察新清宁配合小剂量持续胃肠透析治疗尿毒症的临床疗效。方法 :57例临床确诊的尿毒症患者随机分为 3组 :A组 18例 ,为小剂量持续胃肠透析组 ,口服胃肠透析液 ,每次 10 0 0ml,每天 2～3次 ;B组 2 0例 ,为中西医结合组 ,治疗在A组的基础上加用中药大黄制剂———新清宁 ,每次 5～ 10片 ,每天3次 ;C组 19例 ,为对照组 ,口服包醛氧化淀粉 ,每次 5～ 10 g ,每天 3次。观察患者治疗前后的临床表现、肾功能、营养代谢及电解质酸碱变化 ,疗程 11个月。结果 :与治疗前和对照组比较 ,A、B两组治疗后临床症状明显改善 ,生活质量提高 ,营养状况良好 ,血肌酐 (SCr)、尿素氮 (BUN)、血磷 (SP)、血尿酸 (UA)水平明显下降 ,二氧化碳结合力 (CO2 CP)、内生肌酐清除率 (CCr)、体重及同侧上臂肌围 (AMC)升高。B组除上述变化外 ,血清甘油三酯 (TG)水平亦有所下降 ,肾衰进展速度较A组进一步减慢。C组治疗后各项指标无好转 ,SCr较治疗前明显升高。结论 :中药大黄制剂配合小剂量持续胃肠透析治疗尿毒症疗效确切 ,为慢性肾衰尿毒症非替代疗法提供了一个新的治疗手段。 |
| 英文摘要: |
| To investigate the clinical effect of Xinqingning (XQN), a preparation of rhubarb, combined with low dose continuous gastrointestinal dialysis in treating uremia. Methods: Patients of uremia were divided into three groups at random, eighteen patients in the group A were treated with 1000 ml gastrointestinal dialysate (non-absorbed mannitol solution) orally 2-3 times a day, twenty patients in the group B treated with the same therapy as that in the group A, but combined with XQN 5-10 tablets 3 times per day and 19 patiens in the group C treated by orally taken coated aldehyde oxystarch 5-10 g, 3 times a day. The therapeutic course for the three groups were 11 months. The changes in clinical manifestation, renal function, nutritional condition, and electrolytes before and after treatment were observed. Results: After treatment, significant improvement was revealed in aspects of uremic symptoms, quality of life, nutritional condition, serum creatinine, urea nitrogen, serum phosphate, uric acid, CO 2 combining power, creatine clearance, body weight and arm muscular circumference in the group A and B, as compared with those in the group C. In comparison of the group A and B, the group B showed a lower serum triglyceride and slower progression of chronic renal failure (CRF). All the criteria were not improved in the group C and with serum creatinine raised significantly. Conclusion: XQN combined low dose continuous gastrointestinal dialysis therapy was effective in definitely treating uremia, it provides a new therapeutic means of non-replacement therapy for CRF with uremia. |
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