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Author Name	Affiliation
林松波	LIN Songbo, LIAN Qizhou, PANG Ming, et al. The Affiliated Hospital of Fujian College of Traditional Chinese Medicine, Fuzhou (350004
连棋周	LIN Songbo, LIAN Qizhou, PANG Ming, et al. The Affiliated Hospital of Fujian College of Traditional Chinese Medicine, Fuzhou (350004
庞明	LIN Songbo, LIAN Qizhou, PANG Ming, et al. The Affiliated Hospital of Fujian College of Traditional Chinese Medicine, Fuzhou (350004
梁晖	LIN Songbo, LIAN Qizhou, PANG Ming, et al. The Affiliated Hospital of Fujian College of Traditional Chinese Medicine, Fuzhou (350004
陈忠良	LIN Songbo, LIAN Qizhou, PANG Ming, et al. The Affiliated Hospital of Fujian College of Traditional Chinese Medicine, Fuzhou (350004
孙光	LIN Songbo, LIAN Qizhou, PANG Ming, et al. The Affiliated Hospital of Fujian College of Traditional Chinese Medicine, Fuzhou (350004
谢尧政	LIN Songbo, LIAN Qizhou, PANG Ming, et al. The Affiliated Hospital of Fujian College of Traditional Chinese Medicine, Fuzhou (350004

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中文摘要:

目的 :探讨急性脑梗塞 (ACI)急性血瘀期辨证分型与其关系 ,提出ACI急性血瘀期证的量化标准与意见。方法 :测定 66例ACI急性血瘀期患者 ,分别测定血管内皮细胞活性因子 ,并与健康人 ( 2 0名 )作比较。结果 :( 1)标证中以“痰”、“瘀”为主的风痰瘀血、气虚血瘀、痰热腑实证均见组织型纤溶酶原激活剂(t PA)活性下降 (P <0 0 5) ,其中以气虚血瘀证活性型t PA下降更为明显 (P <0 0 1) ;而以本虚为主的阴虚风动证 ,则见活性型t PA含量增高 (P <0 0 5) ;肝阳上亢及阴虚风动证以 6 酮前列腺素F1α( 6 keto PGF1α)下降显著 (P <0 0 1)。 ( 2 )经逐步回归判别 ,虽然影响急性血瘀严重程度与t PA活性、神经系统缺损积分以及年龄增长等三因素等有关 ,但单因素直线相关分析 ,不存在密切的正负关系。 ( 3)影响神经系统缺损积分经统计学分析 ,与血瘀积分呈正相关 (r =0 70 ,P <0 0 1)。结论 :( 1)风痰瘀血、气虚血瘀、痰热腑实证其病变基础主要为纤溶系统活性降低 ,而阴虚风动和肝阳上亢证则见前列腺素系统活性降低。多指标综合分析 ,有助于中医对ACI急性血瘀期证型的判别。 ( 2 )单一指标无助于区别ACI急性血瘀期型别 ,其改变仅能说明血瘀存在 ,究属哪一型别 ,应做综合分析加以判断。 ( 3)影响神经系统缺损积

英文摘要:

To explore the multiple parameters of TCM Syndrome-types and the acute cerebral infarction (ACI) with blood stasis type. Methods: Sixty-six acute cerebral infarction patients with blood stasis Syndrome, various vascular active factors such as tissue plasminogen activator (t-PA), the activity of plasminogen activator inhibitor (PAI), the concentration of prostaglandin F 1α (6-keto-PGF 1α ) etc. were determined. Results: (1) In Incidental Syndrome, those“Phlegm” and “stasis”predominant, mainly manifested as Wind-Phlegm-Blood stasis (WPBS), Qi deficiency-blood stasis (QDBS) and Phlegm-Heat-bowel excess (PHBE) Syndrome all showed t-PA activity lowered, among them, QDBS Syndrome lowered more obviously (P<0.01); and in fundamental deficiency predominant Syndrome such as Yin-deficiency and Wind-move (YDWM) Syndrome, the active t-PA content increased (P<0.05); in Liver Yang ascending (LYA) Syndrome and YDWM Syndrome, the 6-keto-PGF 1α lowered very significantly. (2) Through regression analysis, although influencing the severity of acute blood stasis was related with 3 factors (t-PA activity, nervous system defect score and age growth), but single factor linear relationship analysis indicated that did not existed positive-negative relationship. (3) Through statistical analysis, the factor influencing nervous system defect scores was positively related with blood stasis score (r=0.70, P<0.01). Conclusion: (1) The basis of WPBS, QDBS and PHBE Syndrome mainly was fibrinolytic system activity lowering, and YDWM and LYA Syndrome prostaglandin system activity lowering. Comprehensive analysis of multiple parameters would be helpful to differentiate the ACI blood stasis stage. (2) Single parameter would not help to differentiate the types of ACI blood stasis stage, its change merely denoted the existence of blood stasis, its type should be differentiated after comprehensive analysis. (3) Those influencing nervous system scoring, mainly was blood stasis score, which suggested that the importance of activating blood circulation to remove stasis in preventing and treating ACI. (4) Put forward ACI blood stasis, and the quantification for new standard of Syndrome for discussion.

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