| 李新民,马融,鲁斌,李少川.肾病合剂对阿霉素肾病大鼠肝组织白蛋白基因表达影响的实验研究[J].,2001,(4):280-282 |
| 肾病合剂对阿霉素肾病大鼠肝组织白蛋白基因表达影响的实验研究 |
| Study on Effect of Nephropathy Mixture on Genetic Expression of Liver Albumin in Rats with Adriamycin-Induced Nephrotic Syndrome |
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| DOI： |
| 中文关键词: 肾病合剂 肾病综合征 白蛋白 基因表达 |
| 英文关键词:Nephropathy mixture nephrotic syndrome albumin gene expression |
| 基金项目:天津市自然科学基金!资助项目 (No .941 4 0 90 1 9) |
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| 中文摘要: |
| 目的 :探讨肾病合剂对阿霉素肾病大鼠肝组织白蛋白基因表达的作用。方法 :建立阿霉素肾病大鼠模型 ,采用Northern杂交及Dot blot定量分析 ,观察肝组织白蛋白mRNA的表达水平。结果 :肾病合剂组大鼠肝组织白蛋白mRNA表达均明显高于模型组及正常组 (P <0 0 5)。结论 :肾病合剂可上调阿霉素肾病大鼠肝组织白蛋白mRNA的表达水平 ,促进白蛋白合成。 |
| 英文摘要: |
| Objective: To explore the effect of Nephropathy mixture on genetic expression of liver albunin in rats with adriamycin induced nephrotic syndrome. Methods: The rat model of adriamycin induced nephrotic syndrome was established and the liver albumin mRNA expression level was observed with Northern hybridization and Dot blot quantitative analysis. Results: The liver albumin mRNA expression level in the Nephropathy Mixture treated group was significantly higher than that in the model group and the normal control group (P<0 05). Conclusion: Nephropathy Mixture could up regulate the liver albumin mRNA expression level and promote the synthesis of albumin in rats with adriamycin induced nephrotic syndrome. |
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