| 谢方云,曾智帆,黄惠英,赵充,卢泰祥.放疗联合人参多糖注射液治疗鼻咽癌的临床观察[J].,2001,(5):332-334 |
| 放疗联合人参多糖注射液治疗鼻咽癌的临床观察 |
| Clinical Observation on Nasopharyngeal Carcinoma Treated with Combined Therapy of Radiotherapy and Ginseng Polysaccharide Injection |
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| DOI： |
| 中文关键词: 鼻咽癌 放射疗法 人参多糖注射液 |
| 英文关键词:nasopharyngeal cancer radiotherapy Ginseng polysaccharide injection |
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| 中文摘要: |
| 目的 :观察放射治疗联合人参多糖注射液治疗鼻咽癌的疗效和对免疫功能的影响。方法 :将131例初治鼻咽癌患者随机分为放疗联合人参多糖组 ( 64例 )和常规放疗组 ( 67例 ) ,观察两组局部肿瘤消退率 ,1年总生存率 ,无瘤生存率及无远处转移生存率 ,观察两组治疗前后T细胞亚群、自然杀伤 (NK)细胞活性及淋巴因子 激活杀伤 (LAK)细胞活性的变化。结果 :两组治疗后 3个月临床检查 ,放疗联合人参多糖组和常规放疗组鼻咽肿瘤完全消退率分别为 96 6%和 93 3% ,颈淋巴结转移灶完全消退率分别为 85 7%和78 0 % ,鼻咽肿瘤CT消退率分别为 60 3%和 51 7% ;放疗后 1年总生存率分别为 10 0 0 %及 96 5% ,放疗后 1年无瘤生存率分别为 84 4 %及 74 6% ,放疗后无远处转移生存率分别为 93 8%及 88 1%。放疗联合人参多糖组外周血NK细胞及LAK细胞活性增高 ,T3、T4 值增高 (均P <0 0 5) ,常规放疗组治疗前后外周血T3、T4 值降低 (P <0 0 5) ,NK细胞、LAK细胞活性差异无显著性 ,未发现人参多糖有毒副作用。结论 :人参多糖在放疗中对改善鼻咽癌患者机体免疫功能有一定的作用 ,并减轻放疗反应和改善患者一般状况 |
| 英文摘要: |
| Objective: To observe the effect of radiotherapy (RT) combined with Ginseng polysaccharide (GSP) injection in treating nasopharyngeal carcinoma (NPC) and its influence on immune function. Methods: One hundred and thirty one NPC patients were randomly divided into two groups, 64 cases in the RT GSP group treated with RT GSP and 67 in the control group treated with conventional therapy, to observe the local cancer remission rate, 1 year total survival rate, no tumor survival rate and no remote metastasis survival rate. Moreover, the changes of T lymphocyte subsets, natural killer (NK) cell activity and lymphocyte activated killer (LAK) cell activity before and after treatment were observed. Results: Clinical examination conducted 3 months after treatment showed that the complete remission rete in the RT GSP group was 96.6%, and in the control group 93.3%, the complete remission rate of cervical node metastatic tumor in the two groups was 85.7% and 78.0% respectively, and the NPC CT remission rate 60.3% and 51.7% respectively. Re examination carried out 1 year after RT treatment showed that the total survival rate in the two groups was 100% and 96.5%, no tumor survival rate 84.4% and 74.6%, and no remote metastasis survival rate was 93.8% and 88.1% respectively. The activity of NK cell and LAK cell as well as T 3、T 4 value in peripheral blood increased significantly in the RT GSP group (all P<0 05) after treatment, while in the control group, activity of NK cell and LAK cell changed insignificantly after treatment, and T 3, T 4 value lowered significantly (P<0 05). No toxic adverse reaction of GSP was found. Conclusion: GSP has certain improving immune function effect in NPC patients during RT, it could also eliminate the occurred adverse reaction to RT and the general condition of patients. |
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