| 赵玲,徐秋萍,唐民科.聪圣胶囊对鼠脑缺血损伤的保护及对脑血流与能量代谢的改善作用[J].,2001,(5):375-377 |
| 聪圣胶囊对鼠脑缺血损伤的保护及对脑血流与能量代谢的改善作用 |
| Experimental Study on Protective Effect of Congsheng Capsule in Acute Cerebral Ischemia and Improvement of Cerebral Blood Flow and Energy Metabolism |
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| DOI： |
| 中文关键词: 聪圣胶囊 脑缺血 血流量 能量代谢 |
| 英文关键词:Congsheng capsule cerebral ischemia blood flow energy metabolism |
| 基金项目:国家“九五”攻关课题! (No .96 - 90 6 - 0 9- 0 3) |
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| 中文摘要: |
| 目的 :研究聪圣胶囊对鼠脑缺血的保护作用。方法 :采用三氯化铁阻断大鼠一侧大脑中动脉、结扎大鼠双侧颈总动脉、高龄小鼠双侧颈总动脉反复缺血再灌注合并尾部放血的方法造成脑缺血模型 ,分别观察聪圣胶囊对神经症状、脑梗塞面积和脑含水量、脑血流量、脑组织能量代谢的影响。结果 :聪圣胶囊1、3、6g/kg显著降低脑梗塞面积和脑含水量 ,明显改善神经症状和脑血流量 ;3、6g/kg明显改善能量负荷。结论 :聪圣胶囊可通过增加脑组织血液供应 ,改善能量代谢 ,从而发挥抗脑缺血作用 |
| 英文摘要: |
| Objective: To investigate the protective effect of Congsheng capsule (CSC) on acute cerebral ischemia in mice and rats. Methods: Cerebral ischemia model was established by adding FeCl 3 to block the blood flow of unilateral middle cerebral artery (MCA) for 30 mins. Acute incomplete cerebral ischemia was induced by ligation of bilateral carotid arteries in rats. Bilateral carotid arteries of old mice were repeatedly ischemia and reperfusion combined with caudal bloodletting to build the cerebral ischemia model. The effect of CSC on neurologic symptom, cerebral infarction size, cerebral water content, cerebral blood flow and cerebral tissue energy metabolism were observed. Results: CSC 1, 3, 6 g/kg obviously reduce the size of cerebral infarction and cerebral water content, markedly improve the neurological symptoms and cerebral blood flow; 3, 6 g/kg significantly ameliorate the energy burden. Conclusion: CSC has anti cerebral ischemia function through increasing blood supply of cerebral tissue and improve the energy metabolism |
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