| 孔平孝,陈光伟,王希胜,朱德生,刘文英,娄清林,李新民.天佛参口服液治疗中晚期恶性肿瘤的临床与实验研究[J].,2001,(6):427-430 |
| 天佛参口服液治疗中晚期恶性肿瘤的临床与实验研究 |
| Clinical and Experimental Study on Treatment of Moderate and Advanced Malignant Tumors with Tianfoshen Oral Liquid |
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| DOI： |
| 中文关键词: 天佛参口服液 恶性肿瘤 人胃癌细胞 人肝癌细胞 小鼠乳腺癌细胞 |
| 英文关键词:Tianfoshen oral liquid malignant tumor human gastric cancer cell human liver cancer cell mice galactophore cancer cell |
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| 中文摘要: |
| 目的 :观察天佛参口服液 (TFS)对中晚期恶性肿瘤的临床疗效并探讨其作用机理。方法 :对用TFS治疗的 71例恶性肿瘤患者按实体瘤疗效标准进行疗效分析 ,评定其生存质量、3年存活率及免疫功能的变化。并经实验用集落形成法测定对人胃癌 (MGC80 3)细胞、人肝癌 (SMMC772 1)细胞、小鼠乳腺癌(EMT6 )细胞肿瘤克隆原细胞的抑制作用和应用以上 3种肿瘤染料排斥实验测定对肿瘤细胞生长率的影响。结果 :临床观察 71例患者总缓解率为 4 5 1% ,有效率为 71 8% ,生存质量改善 ,机体免疫力增强 ,治疗1、2及 3年的生存率分别为 78 5%、38 5%及 10 8% ,中位生存时间 2 4 2个月。实验研究表明 ,TFS不但有直接杀伤肿瘤细胞的作用和抑制单个细胞克隆的增殖能力 ;并且具有广谱的抗肿瘤作用和一定的量效关系 ,与对照药物比较差异有显著性 (P <0 0 5)。结论 :TFS对中晚期恶性肿瘤有明显疗效 ,其抗癌作用与机体免疫力增强和直接抑杀肿瘤细胞有关 |
| 英文摘要: |
| Objective: To investigate the clinical efficacy of Tianfoshen oral liquid (TFS) in treating moderate and advanced malignant tumors and its mechanism. Methods: Therapeutic effect of TFS in treating 71 patients of malignant tumor was analyzed with the criteria, including quality of life, 3 year survival rate and immune function. And experimental studies of inhibitory effect on tumor clone primordial cells and tumor growth rate of TFS on human gastric tumor (MGC 803 ) cell, human liver cancer (SMMC 7721 ) cell and mice galactophore cancer (EMT 6) cell by colony forming method and dye exclusion test respectively were also conducted. Results: Clinical study showed that in the 71 cases treated, the total remission rate was 45.1%, the effective rate 71.8%, with improvement in quality of life and immune function, the 1 , 2 and 3 year survival rate being 78.5%, 38.5% and 10.8% respectively and the mean survival time 24.2 months. Experimental study showed that TFS could kill the cancer cells directly, inhibit the proliferation of single clonogenic cell, and had a broad spectrum dose dependent inhibitory action on various tumors with significant difference in comparing with the effects of the control (P<0 05). Conclusion: TFS had obvious therapeutic effect to moderate and advanced tumors, its anti tumor effect was related to the enhancement of immune function and tumor inhibiting or direct killing action. |
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