| 李尚珠,黄平平,金永娟,傅仁敏,许子亮,李洪钧,王书桂.阿魏酸钠对闭塞性动脉硬化症患者白细胞自发活化及表面粘附分子表达的影响[J].,2001,(7):492-494 |
| 阿魏酸钠对闭塞性动脉硬化症患者白细胞自发活化及表面粘附分子表达的影响 |
| Effect of Sodium Ferulate on Leucocyte Spontaneous Activation and Surface Adhesion Molecule Expression in Arteriosclerosis Obliterans Patients |
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| DOI： |
| 中文关键词: 阿魏酸钠 闭塞性动脉硬化症 白细胞自发活化 粘附分子CD11/CD18 |
| 英文关键词:sodium ferulate arteriosclerosis obliterans leucocyte spontaneous activation rate adhesion molecule CD11/CD18 |
| 基金项目:国家中医药管理局重点基金资助 (No .95A1 1 3) |
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| 中文摘要: |
| 目的 :探讨阿魏酸钠对闭塞性动脉硬化症 (ASO)患者的白细胞自发活化和表面粘附分子表达的影响。方法 :用阿魏酸钠治疗ASO患者 4 2例 ,观察治疗前后的白细胞自发活化率和表面粘附分子CD11/CD18表达率的变化 ,并与同期观察的 3 6名健康人作为对照。结果 :4 2例患者近期治愈 17例( 4 0 5% ) ,显效 2 1例 ( 50 0 % ) ,有效 2例 ( 4 8% ) ,无效 2例 ( 4 8% ) ,总有效率为 95 2 %。 4 2例患者治疗前白细胞自发活化率〔( 14 84± 7 54) %〕和表面粘附分子CD11/CD18表达率〔( 4 7 94± 13 4 8) %〕均明显高于健康人〔( 4 96± 2 0 4 ) %和 ( 2 4 12± 9 3 5) %〕 ,治疗后均有所下降〔( 8 19± 4 0 9) %和 ( 2 8 63± 7 91) %〕 ,差异有显著性 (P <0 0 1)。结论 :阿魏酸钠治疗ASO不仅疗效显著 ,而且对其白细胞自发活化和表面粘附分子CD11/CD18表达也有明显的抑制作用 |
| 英文摘要: |
| Objective: To explore the effect of sodium ferulate (SF) on leucocyte spontaneous activation rate (LSAR) and the surface expression of adhesion molecule (SEAM) in patients with arteriosclerosis obliterans (ASO). Methods: Forty two patients with ASO were treated by SF, LSAR and SEAM in them were determined qualitatively before and after SF treatment, as well as in 36 healthy subjects for control. Results: Therapeutic effect of SF in the treated 42 patients was short term cured in 17 cases (40.5%), markedly effective in 21 (50%), effective in 2 (4.8%), ineffective in 2(4.8%), and the total effective rate being 95.2%. LSAR and SEAM in ASO patients before treatment was 14.84±7.54% and 47.94±13.48% respectively, which was obviously higher than 4.96±2.04% and 24.12±9.35% in healthy subjects (P<0 01) respectively, but markedly reduced to 8.19±4 09% and 28.63±7.91% after SF treatment (P<0 01). Conclusion: SF could not only obviously lower both LSAR and SEAM but also exert a good therapeutic effect on patients with ASO. |
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