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Author Name	Affiliation
GUO Li zhong	南京中医药大学
MAO Wei	广东省中医院
WANG Hong mei	空军临潼疗养院
刘玉宁	成都中医药大学
叶传蕙	成都中医药大学

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中文摘要:

目的 :探讨肾康注射液与苯那普利对人肾小球系膜细胞 (MC)增殖的不同抑制作用强度。方法 :采用体外培养的人肾小球系膜细胞技术和血清药理学方法 ,观察具有降逆泄浊、益气活血作用的中药肾康注射液及苯那普利对MC增殖的影响。结果 :肾康注射液与苯那普利对MC增殖均具有抑制作用 ,但在等效剂量浓度下 ,肾康注射液对MC的抑制作用优于苯那普利。结论 :MC是肾康注射液发挥治疗作用的重要靶细胞 ,抑制MC增殖可能是该方延缓肾小球硬化的重要机制之一。

英文摘要:

To explore the intensity of inhibitory function of Shenkang injection (SKI), a Chinese herbal recipe, and benazepril on the proliferation of human glomerular mesangial cell (MC). Methods: The effect of SKI and benazepril on the proliferation of human MC was observed by using the cultured MC in vitro and serum pharmacological assay. Results: Both SKI and benazepril could inhibit the proliferation of human MC, but in equal dosage consistency, SKI showed a better inhibitory effect than that of benazepril. Conclusion: MC is the important target cell for the action of SKI, the inhibiting on proliferation might be one of the essential mechanisms of SKI in retarding glomerulosclerosis.

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