| 邬亚军,劳志英,张之澧.小剂量雷公藤多甙和氨甲蝶呤联合治疗类风湿性关节炎的临床观察[J].,2001,(12):895-896 |
| 小剂量雷公藤多甙和氨甲蝶呤联合治疗类风湿性关节炎的临床观察 |
| Clinical Observation on Small Doses Tripterygium Wilfordii Polyglycoside Combined with Methotrexate in Treating Rheumatoid Arthritis |
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| DOI： |
| 中文关键词: 雷公藤多甙 氨甲蝶呤 类风湿性关节炎 |
| 英文关键词:Tripterygium wilfordii polyglycoside methotrexate rheumatoid arthritis |
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| 中文摘要: |
| 目的 :观察小剂量雷公藤多甙和氨甲蝶呤联合治疗类风湿性关节炎的疗效和不良反应。方法 :将 70例患者随机分为雷甲组 (雷公藤多甙和氨甲蝶呤联合治疗组 ) ,对照组 (氨甲蝶呤治疗组 )。 2组均继续应用原有非甾类抗炎药。对照组加服氨甲蝶呤 15mg ,每周 1次 ;雷甲组加服雷公藤多甙 10mg ,每天 3次 ,氨甲蝶呤 7 5mg ,每周 1次。观察治疗后的临床疗效及不良反应。 结果 :对照组显效率为 2 8 6 % ,雷甲组为 34 3% ,两组比较 ,差异无显著性 (u =0 5 0 2 8,P >0 0 5 )。两组治疗前后临床症状、体征及血沉、类风湿因子 (RF)的变化 ,经统计学处理 ,差异均有显著性 (P <0 0 1)。不良反应对照组发生 2 0例次 ,雷甲组发生 8例次。结论 :小剂量雷公藤多甙和氨甲蝶呤联合治疗类风湿性关节炎疗效佳 ,不良反应少 |
| 英文摘要: |
| Objective: To observe the effect and adverse reaction of small doses Tripterygium wilfordii polyglycoside (TWP) combined with methotrexate (MT) in treating rheumatoid arthritis (RA). Methods: Seventy RA patients were randomly divided into two groups, the control group (35 patients) and the TWP combined MT Group (TWPM group). Both of them were continued to use the non steroidal anti inflammatory drugs. The control group took MT 15mg orally, once every week; the TWPM group took TWP 10mg orally, 3 times a day, and MT 7.5mg orally once every week. The clinical effect and adverse reaction after treatment were evaluated. Results: The markedly effective rate in the control group and the TWPM group was 28.6% and 34.3% respectively, with no significant difference (P>0 05). Data of symptoms and signs, erythrocyte sedimentation rate (ESR), rheumatoid factor (RF) were determined respectively with significant difference (P<0 01). The rate of adverse reaction was 20 cases times in the control group and 8 cases times in the TWPM group. Conclusion: MT combined small doses of TWP in treating RA has better effect and less adverse reactions than un combined MT. |
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