| 连方,张宁,张建伟,王玉东,王希波.贞芪转阴汤配合宫腔内人工授精治疗女性抗精子抗体阳性脾肾两虚型不育症的临床观察[J].,2002,(2):95-97 |
| 贞芪转阴汤配合宫腔内人工授精治疗女性抗精子抗体阳性脾肾两虚型不育症的临床观察 |
| Clinical Observation on Effect of Zhenqi Zhuanyin Decoction Combined with Intrauterine Insemination in Treating Spleen-Kidney Deficiency Type Patients of Sterility with Positive Anti-sperm Antibody |
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| 中文关键词: 贞芪转阴汤 宫腔内人工授精 不育 女(雌)性 抗精子抗体 |
| 英文关键词:Zhenqi Zhuanyin Decoction intrauterine insemination infertility female antisperm antibody |
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| 中文摘要: |
| 目的 :比较贞芪转阴汤配合宫腔内人工授精 (IUI)与单纯IUI、单纯贞芪转阴汤治疗女性抗精子抗体AsAb阳性不育的疗效。方法 :10 3例AsAb阳性、中医辨证属脾肾两虚型女性不育症患者 ,随机分为 3组 :A组用贞芪转阴汤配合适时IUI治疗 (34例 ) ;B组用贞芪转阴汤治疗 (34例 ) ;C组适时IUI治疗(35例 )。观察各组AsAb转阴情况、妊娠率、转阴妊娠率、中医证候疗效及T细胞亚群改变。结果 :(1)A、B、C组AsAb转阴率依次分别为 76 4 7% (2 6 / 34例 )、82 35 % (2 8/ 34例 )、8 5 7% (3/ 35例 )。 (2 )A组妊娠率4 1 18% (14/ 34例 ) ,转阴妊娠率 5 0 0 0 % (13/ 2 6例 ) ;B组妊娠率 2 0 5 9% (7/ 34例 ) ,转阴妊娠率 2 1 4 3%(6 / 2 8例 ) ;C组妊娠率 11 4 3% (4/ 35例 )。A、B组妊娠率及转阴妊娠率比较 ,差异均有显著性 (P <0 0 1) ,A、C组妊娠率比较差异有显著性 (P <0 0 1)。 (3)A、B组患者中医症候有效率分别为 88 2 3%、91 18% (P>0 0 5 )。 (4)A、B组治疗后CD4 下降 ,CD8上升 ,CD4 /CD8比值下降 ,与本组治疗前及C组治疗后比较差异有显著性 (P <0 0 5 ,P <0 0 1)。结论 :对女性AsAb阳性所致的不育症 ,以补肾健脾益气为法的贞芪转阴汤配合适时IUI的中西医结合方法治疗 ,疗效优于单纯贞芪转阴汤治疗及单纯 |
| 英文摘要: |
| Objective: To compare the effect of combined therapy of Zhenqi Zhuanyin Decoction (ZQZYD) and timely intrauterine insemination (IUI) with that of using ZQZYD and IUI separately in treating patients of sterility with positive anti sperm antibody (AsAb). Methods: One hundred and three patients were randomly divided into 3 groups, 34 patients in Group A treated with combined ZQZYD and IUI, 34 in Group B treated with ZQZYD alone and 35 in Group C treated with IUI alone. The negative conversion rate of AsAb, pregnancy rate in patients, pregnancy rate in AsAb converted patients, as well as changes of TCM Syndrome and T lymphocyte subsets were observed. Results: (1)The negative conversion rate of AsAb in the 3 groups was 76.47 %(26/34), 82.35%(28/34) and 8.57%(3/35) respectively. (2)In Group A, the pregnancy rate was 41.18%(14/34), pregnancy rate in AsAb negative converted patients was 50.0%(13/26); in Group B, the respective criteria was 20.59%(7/34) and 21.43%(6/28) respectively; and in Group C, the pregnancy rate was 11.43%(4/35). The pregnancy rate in Group A was significantly higher than that in Group B or C (P<0 01). (3) The effective rate on TCM Syndrome in Group A and B was 88.23% and 91.18% respectively (P>0 05). (4)In Group A and B, CD 4 decreased, CD 8 increased and CD 4/CD 8 ratio decreased after treatment, which were significantly different from those before treatment and in Group C after treatment (P<0 05). Conclusion: Combined therapy of ZQZYD and IUAI shows a better effect in treating infertility with positive AsAb than that by ZQXYD or IUI alone. |
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