| 李作孝,谭华,熊先骥,彭建一,陈枫.雷公藤多甙辅助治疗重症肌无力临床疗效及对血清IL-6的影响[J].,2002,(3):175-177 |
| 雷公藤多甙辅助治疗重症肌无力临床疗效及对血清IL-6的影响 |
| Clinical Effect of Tripterygiitotorum Combined with Prednisone and Its Effect on Serum IL-6 Level in Treating Patients with Myasthenia Gravis |
| |
| DOI： |
| 中文关键词: 雷公藤多甙 强的松 重症肌无力 白细胞介素6 B淋巴细胞 |
| 英文关键词:Tripterygiitotorum prednisone myasthenia gravis interleukin 6 B lymphocyte |
| 基金项目: |
|
| Hits: 1262 |
| Download times: 1488 |
| 中文摘要: |
| 目的 :探讨雷公藤多甙 (TⅡ )联合强的松治疗重症肌无力 (MG)的临床疗效及免疫功能的变化。方法 :将 6 8例MG患者随机分为两组 ,治疗组 (36例 )采用TⅡ联合强的松治疗 ,对照组 (32例 )单用强的松治疗 ,观察两组临床疗效及治疗前后血清白细胞介素 6 (IL 6 )水平和周围血B淋巴细胞含量变化。结果 :治疗组临床疗效优于对照组 (P <0 0 5 ) ,两组治疗后血清IL 6水平及周围血B淋巴细胞含量较治疗前明显降低 (P <0 0 1) ,两组治疗后比较 ,差异有显著性 (P <0 0 5 )。结论 :TⅡ联合强的松治疗MG疗效较单用强的松更好 ,其免疫抑制作用比单用强的松更强 |
| 英文摘要: |
| Objective: To explore the clinical effect of Tripterygiitotorum (TⅡ) combined with prednisone in treating patients with myasthenia gravis (MG) and the changes of immune function after treatment. Methods: Sixty eight patients with MG were randomly divided into two groups, the 36 patients in the treated group were treated with TⅡ plus prednisone and the 32 in the control group were treated with prednisone alone. The therapeutic effect, serum interleukin 6 (IL 6) and peripheral B lymphocyte levels were observed. Results: The therapeutic effect in the treated group was significantly higher than that in the control group (P<0 05). There were significant decrease in serum IL 6 and peripheral B lymphocyte in both groups after treatment (P<0 05), with the decrements more significant in the treated group (P<0 05). Conclusion: The therapy of TⅡ plus prednisone is superior to that of prednisone alone in treating MG, it has a more potent effect of immunosuppression. |
| View Full Text View/Add Comment Download reader |
