| 许能贵,易玮,赖新生,靳瑞.电针对局灶性脑缺血大鼠脑细胞内Ca2+含量的影响[J].,2002,(4):295-297 |
| 电针对局灶性脑缺血大鼠脑细胞内Ca2+含量的影响 |
| Effect of Electro-Acupuncture on Calcium Content in Neurocytes of Focal Cerebral Ischemia |
| |
| DOI： |
| 中文关键词: 电针 激光共聚焦扫描显微镜 局灶性脑缺血 钙离子 大鼠 |
| 英文关键词:electro acupuncture laser confocal scanning microscope focal cerebral ischemia calcium content rat |
| 基金项目:国家自然科学基金资助 (No .3950 0 1 92 ) |
|
| Hits: 1104 |
| Download times: 1458 |
| 中文摘要: |
| 目的 :研究电针对局灶性脑缺血大鼠脑细胞内Ca2 +的调节作用。方法 :利用激光共聚焦扫描显微镜观察缺血区活体脑片中脑细胞内Ca2 +的变化。结果 :缺血 1h ,皮质部细胞内Ca2 +含量还未出现明显变化 ,而纹状体部细胞内Ca2 +的含量明显升高 ;缺血 3h ,皮质部和纹状体细胞内Ca2 +含量均出现显著的升高 ,且纹状体细胞内Ca2 +含量明显高于皮质部 ;缺血 3h并给予电针治疗 30min后 ,则皮质部和纹状体细胞内Ca2 +含量均出现明显的下降。结论 :电针可迅速调节缺血区脑细胞内的Ca2 +含量 ,抑制胞内Ca2 +超载 ,从而保护脑缺血后继发神经元的损伤。 |
| 英文摘要: |
| Objective: To study the effect of electro acupuncture (EA) in regulating calcium (Ca 2+ ) content in brain neurocytes of rats with focal cerebral ischemia. Methods: The changes of Ca 2+ content in ischemic neurocytes were observed by using laser confocal scanning microscope. Results: Ca 2+ content did not change significantly in cerebral cortex when the brain ischemia occurred for 1 hr, but it raised significantly in striatum neurocytes. Both the Ca 2+ contents in striatum and cortex area increased significantly 3 hrs after ischemia occurrence and the content in striatum was higher than that in cortex significantly. Brain Ca 2+ content could be reduced significantly after the 3 hrs ischemic brain were treated by EA for 30 min. Conclusion: EA could regulate the content of Ca 2+ in the ischemic area of brain, inhibit Ca 2+ overload, so as to protect neurons from ischemic injury. |
| View Full Text View/Add Comment Download reader |
