| 梁铁军,张伟,张才擎,贾新华,王哲.抗纤保肝汤治疗慢性乙型肝炎肝纤维化的临床研究[J].,2002,(5):332-334 |
| 抗纤保肝汤治疗慢性乙型肝炎肝纤维化的临床研究 |
| Clinical Study on Treatment of Liver Fibrosis in Patients of Hepatitis B by Kangxian Baogan Decoction |
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| DOI： |
| 中文关键词: 抗纤保肝汤 肝纤维化 肝活检 |
| 英文关键词:Kangxian Baogan Decoction liver fibrosis liver biopsy |
| 基金项目: |
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| 中文摘要: |
| 目的 :研究抗纤保肝汤的临床疗效及作用机理。方法 :慢性乙型肝炎患者 81例 ,随机分为治疗组 (5 4例 )和对照组 (2 7例 ) ,分别给予抗纤保肝汤及一般保肝药物治疗 6个月 ,观察两组患者治疗前后血清透明质酸 (HA)、Ⅲ型前胶原 (PCⅢ )、Ⅳ型胶原 (C Ⅳ )、层粘蛋白 (LN)、转化生长因子 β1(TGFβ1)、肿瘤坏死因子α(TNF α)水平 ,肝功能变化及肝脏病理组织改变。结果 :治疗组临床各症状缓解率明显优于对照组(P <0 0 5 ) ,治疗后治疗组患者血清HA、PCⅢ、C Ⅳ、LN、TGFβ1、TNF α显著下降 ,肝功能明显改善 ,与对照组比较差异均有显著性 (P <0 0 5或P <0 0 1) ,肝脏活组织病理检查证实肝纤维组织减少。结论 :抗纤保肝汤具有显著抗肝纤维化作用。 |
| 英文摘要: |
| Objective: To explore the clinical effect and therapeutic mechanism of Kangxian Baogan Decoction (KXBGD) on liver fibrosis caused by chronic hepatitis B. Methods: Eight one patients with chronic hepatitis B were divided into two groups randomly. The 54 patients in the treated group were treated by KXBGD and the 27 patients in the control group were treated by conventional liver protecting treatment. Serum levels of hyaluronic acid (HA), procollagen type Ⅲ (PCⅢ), collagen type Ⅳ(C Ⅳ), laminin (LN), transforming growth factor β 1(TGFβ 1) and tumor necrosis factor α (TNF α) were measured before and after treatment, meanwhile, liver function and pathological changes of liver tissues were observed. Results: The total effective rate in the treated group was significantly higher than that in the control group. Serum levels of HA, PCⅢ, C Ⅳ, LN, TGFβ 1 and TNF α in the treated group obviously reduced after treatment, and the liver function got better with significant difference as compared with those in the control group (P<0 05 or P<0 01). Pathological examination of liver biopsy showed that the fibrous tissue in the liver reduced. Conclusion: KXBGD has a definite effect of anti liver fibrosis. |
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