| 林水淼,王健,周如倩,郁志华.从心、肾论治阿尔茨海默病的临床研究[J].,2003,(8):583-586 |
| 从心、肾论治阿尔茨海默病的临床研究 |
| Clinical Study on Treatment of Alzheimer′s Disease from the Viewpoint of Xin and Shen |
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| DOI： |
| 中文关键词: 调心方 补肾方 阿尔茨海默病 |
| 英文关键词:Tiaoxin Recipe Bushen Recipe Alzheimer′s disease |
| 基金项目:国家“九五”中医药科技攻关项目 (No .9690 60 90 1 ) |
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| 中文摘要: |
| 目的 :探讨调心方、补肾方治疗阿尔茨海默病 (Alzheimer′sdisease ,AD)的疗效机制。方法 :将 6 0例AD患者根据治疗前简易智能状态检查量表 (MMSE)、日常生活能力量表 (ADL)的分值 ,采用随机区组设计分为 3组 ,分别用调心方、补肾方和多奈哌齐治疗 12周 ,观察治疗前后 3组患者MMSE、ADL和神经心理学量表 (FOM、RVR、DS、BD)积分以及操作性总评等指标的变化。结果 :3组均能改善AD患者的认知功能和日常生活能力 ,治疗前后MMSE分值 :调心方组分别为 (16 10± 1 94 )分、(17 90±2 5 9)分 ;补肾方组为 (16 15± 2 16 )分、(17 5 0± 2 5 9)分 ;多奈哌齐组为 (17 35± 1 90 )分、(19 6 0± 3 39)分 ;治疗前后比较 ,差异均有显著性 (P <0 0 1)。治疗前后ADL分值 :调心方组分别为 (4 3 10± 3 86 )分、(4 1 5 0± 4 4 0 )分 ;补肾方组为 (4 3 30± 4 5 3)分、(4 1 6 0± 4 12 )分 ;多奈哌齐组为 (4 2 95± 3 5 8)分、(4 0 6 0± 5 2 3)分 ;治疗前后比较 ,差异亦有显著性 (P <0 0 5或P <0 0 1) ;调心方、多奈哌齐均能增加FOM、RVR、DS分值 ,补肾方可增加RVR、BD分值 ,治疗前后比较 ,差异均有显著性 (P <0 0 5或P <0 0 1) ;其中FOM分值 ,补肾方组与多奈哌齐两组差值比较 ,差异有显著性 (P <0 0 |
| 英文摘要: |
| Objective:To explore the therapeutic mechanism of Tiaoxin Recipe (TXR) and Bushen Recipe (BSR) in treating Alzheimer′s disease (AD). Methods:Sixty patients with AD were divided into 3 groups according to their MMSE and ADL scores before treatment, using randomized block design. They were treated separately with TXR, BSR and Donepezil (Dp) for 12 weeks. The changes of MMSE score, ADL score, neuro-psychology amount table score, including FOM, RVR, DS and BD, as well as the overall operational evaluation before and after treatment were analyzed. Results:The recognition and daily life capacity of patients in the 3 groups were improved after treatment. MMSE score in the TXR group increased from 16.10±1.94 scores before treatment to 17 90±2 59 scores after treatment, in the BSR group, from 16 15±2 16 to 17 50±2 59, and in the Dp group, from 17 35±1 90 to 19 60±3 39, all showed significant difference (all P<0 01). Change of ADL score showed that in TXR from 43 10±3 86 to 41 50±4 40, in the BSR group from 43 30±4 53 to 41 60±4 12 and in the Dp group, from 42 95±3 58 to 40 60±5 23, which also showed significant difference (P<0 05 or P<0 01). Moreover, increase of FOM, RVR and DS score was shown in the TXR and the Dp group, and increase of RVR and BD score was shown in the BSR group with significant difference in comparison of corresponding score before and after treatment, inter-groups comparison showed significant difference of FOM score between the BSR and the Dp group (P<0 01). Overall operational evaluation (total effective rate) in the TXR group was 70%, in the BSR group 65% and in Dp group 75%, with no significant difference among them. Conclusion:TXR and BSR are effective TCM drugs in treating AD. |
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