| 王丽亚,魏影非,杜惠兰,王素云,张爱群.参附注射液对肠梗阻术后患儿肠功能恢复及细胞免疫、血清IL-2、TNF-α水平的影响[J].,2003,(10):744-746 |
| 参附注射液对肠梗阻术后患儿肠功能恢复及细胞免疫、血清IL-2、TNF-α水平的影响 |
| Effect of Shenfu Injection on Recovery of Intestinal Function, Cellular Immunity, Serum Interleukin-2 and Tumor Necrosis Factor-α in Children with Intestinal Obstruction after Operation |
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| DOI： |
| 中文关键词: 参附注射液 肠梗阻 肠功能 细胞免疫 白细胞介素-2 肿瘤坏死因子-α |
| 英文关键词:Shenfu injection intestinal obstruction intestinal function cellular immunity interleukin-2 tumor necrosis factor-α |
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| 中文摘要: |
| 目的 :观察参附注射液对肠梗阻患儿术后肠功能恢复及T淋巴细胞亚群 (CD4 、CD8、CD4 /CD8) ,血清白细胞介素 2 (IL 2 )和肿瘤坏死因子 α(TNF α)的影响。方法 :将 98例急诊肠梗阻手术后患儿分为参附组 (参附注射液加手术组 ) 5 0例及对照组 (单纯手术组 ) 4 8例 ,观察肠梗阻患儿术后肠功能恢复率及其T淋巴细胞亚群、血清IL 2和TNF α水平。结果 :参附组应用参附注射液治疗 7天后 ,患儿肠功能恢复率(84 0 % )明显高于对照组 (6 2 5 % ,P <0 0 5 ) ;CD4 、CD4 /CD8均较治疗前提高 (P <0 0 5 )。对照组CD8较治疗前明显升高 (P <0 0 5 ) ,并高于参附组 (P <0 0 1)。治疗后两组血清IL 2水平均有增高趋势 ;治疗组明显高于治疗前 (P <0 0 5 ) ,并高于对照组 (P <0 0 5 )。两组治疗后TNF α水平均明显下降 (P <0 0 1) ;参附组血清TNF α水平明显低于对照组 (P <0 0 5 )。结论 :参附注射液能促进肠梗阻患儿术后肠功能恢复 ,改善、调节手术患儿的免疫功能。 |
| 英文摘要: |
| Objective: To observe the effect of Shenfu injection (SFI) on recovery of intestinal function, T-lymphocyte subsets (CD 4, CD 8 and CD 4/CD 8), interleukin-2 (IL-2) and tumor necrosis factor-α (TNF-α) in children with intestinal obstruction after surgical operation. Methods: Ninety-eight children suffering from intestinal obstruction after emergent surgical operation were divided into the SFI group (n=50, treated with SFI after operation) and the control group (n=48, treated with surgical operation alone). The intestinal function recovery rate (IFRR), T-lymphocyte subsets, serum levels of IL-2 and TNF-α in them were observed. Results: After being treated for 7 days, the IFRR in the SFI group was 84.0%, which was significantly higher than that in the control group (62.5%, P<0.05). CD 4, CD 4/CD 8 levels increased in the SFI group after treatment (P<0.05), while in the control group, CD 8 increased significantly after treatment (P<0.05) and higher than that in SFI group (P<0.01). IL-2 level was much higher in the SFI group after treatment than that in the control group (P<0.05). TNF-α level significantly lowered in both groups (P<0.01), and the level in the SFI group was lower than that in the control group (P<0.05). Conclusion: SFI could promote the recovery of intestinal function, improve and regulate the immune function of the children after operation for intestinal obstruction. |
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