| 华苓,吴育宁,张巨明,柴嵩岩,黄玉华,佟庆,张庆.益肾健脾养血通利法治疗多囊卵巢综合征的临床观察[J].,2003,(11):819-822 |
| 益肾健脾养血通利法治疗多囊卵巢综合征的临床观察 |
| Clinical Study of Yishen Jianpi Yangxue Tongli Therapy in Treating Polycystic Ovary Syndrome |
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| DOI： |
| 中文关键词: 益肾健脾养血通利法 多囊卵巢综合征 闭经 脾肾阳虚型 克罗米芬 葡萄糖耐量试验 |
| 英文关键词:Yishen Jianpi Yangxue Tongli Therary polycystic ovary syndrome amenorrhea Pi-shen Yang deficiency type clomiphen oral glucose tolerance test |
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| 中文摘要: |
| 目的:观察益肾健脾养血通利法治疗多囊卵巢综合征(PCOS)的临床疗效,探讨其可能的疗效机制。方法:将107例中医辨证为脾肾阳虚型闭经患者随机分为两组,分别用益肾健脾养血通利中药(治疗组76例)和克罗米芬(对照组31例)治疗,并观察两组患者的疗效以及治疗前后体重指数(BMI)、Ferriman-Gallway的毛发(F-G)评分、血清性激素和葡萄糖耐量试验(OGTT)的变化。结果:两组总有效率比较差异无显著性,但治疗组妊娠率(65.7％)明显高于对照组(25.0％,P<0.01);在BMI、F-G评分、血清睾酮、促黄体生成素及OGTT改善等方面两组比较,差异有显著性(P<0.05)。结论:益肾健脾养血通利法能明显改善PCOS患者的临床症状,提高妊娠率,特别是对耐克罗米芬的PCOS患者仍有良好的治疗作用,其作用机制可能与调节下丘脑—垂体—卵巢轴功能,降低胰岛素抵抗有关。 |
| 英文摘要: |
| Objective: To observe the effect of Yishen Jianpi Yangxue Tongli Therapy (YJYTT) in treating polycystic ovary syndrome (PCOS) and to explore the therapeutic mechanism of YJYTT. Methods: One hundred and seven PCOS patients with syndrome differentiation of TCM as Pi-Shen Yang deficiency were randomly divided into two groups, the treated group ( n =76) was treated with Chinese herbal medicine, while the control group ( n = 31) was treated by clomiphen. The therapeutic effect in both groups and the change of body mass index (BMI), Ferriman-Gallway (F-G) score, serum sex hormones and serum oral glucose tolerance test (OGTT) before and after treatment were observed. Results; The comparison of total effective rate between two groups was insignificantly different, but the pregnancy rate of the treated group (65. 7% ) was markedly higher than that of control group (25.0%, P<0.01). Also, significant difference was shown in the aspect of BMI, F-G score, serum testosterone (T), luteinizing hormone (LH) and OGTT, etc. between the two groups (P<0.05). Conclusion: The YJYTT could markedly improve the clinical symptoms and pregnancy rate of PCOS patients, particularly showing good effect to the clomiphen resistant patients. The mechanism possibly was due to its regulation on hypothalamus-pituitary-ovarium axis and reducing the insulin resistance. |
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