| 陈建永,邱建荣,潘锋,丁勇.枳术丸加减治疗胃食管反流病的临床观察[J].,2004,(1):25-27 |
| 枳术丸加减治疗胃食管反流病的临床观察 |
| Clinical Observation on Treatment of Gastro-esophageal Reflux with Modified Zhizhu Pill |
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| DOI： |
| 中文关键词: 枳术丸 胃食管反流 食管炎 |
| 英文关键词:Zhizhu pill gastro-esophageal reflux esophagitis |
| 基金项目: |
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| 中文摘要: |
| 目的 :观察枳术丸加减方治疗胃食管反流病 (gastro esophagealrefluxdisease ,GERD)的疗效 ,并探讨其作用机制。方法 :将 6 3例GERD患者随机分为治疗组 (30例 )和对照组 (33例 ) ,治疗组以枳术丸加减方治疗 ,每日 1剂 ,分 2次服 ,每次 10 0ml,餐前 0 5h服 ;对照组以雷尼替丁片 0 15 g ,每天 2次 ,西沙比利片 10mg ,每天 3次 ,均餐前服 ,疗程均为 8周。分别检测和记录两组治疗前后症状评分、内镜检查、食管压力测定、2 4hpH监测和胃动素 ,观察上述指标治疗前后两组间变化情况。结果 :两组治疗后其症状积分、食管压力测定、2 4hpH监测和血胃动素水平均较治疗前有改善 (P <0 0 5 ) ,且治疗组较对照组改善更为明显(P <0 0 5 )。结论 :枳术丸加减方具有较好的治疗GERD效果。 |
| 英文摘要: |
| Objective:To observe the therapeutic effect of modified Zhizhu pill (ZZP) in treating gastro-esophageal reflux disease (GERD) and to explore its mechanism. Methods:Sixty-three GERD patients were randomly divided into the treated group (n=30) and the control group (n=33). The treated group was treated with ZZP 100 ml, twice daily by orally taking half an hour before meal. The control group was treated with Ranitidine 0.15 g, twice daily and Cisapride 10 mg, three times a day by orally taking before meal. The therapeutic course for both groups was 8 weeks. The changes of symptom scoring, endoscopic examination, esophageal pressure, 24 hrs monitoring on pH and blood level of motilin in the two groups were recorded and compared. Results:After treatment, the symptom scoring, esophageal pressure, 24 hrs monitoring on pH and blood motilin level were improved in both groups (P<0.05), and the improvement in the treated group was more significant than that in the control group (P<0.05). Conclusion:ZZP has good effect in treating GERD. |
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