| 张姗姗,许勇钢,杨晓红,杨经敏,刘锋,麻柔.微小残留白血病患者细胞免疫功能与中医分型关系的研究[J].,2004,(1):36-40 |
| 微小残留白血病患者细胞免疫功能与中医分型关系的研究 |
| Study on Relationship between Cellular Immunity and TCM Typing in Patients with Minimal Residual Leukemia |
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| DOI： |
| 中文关键词: 微小残留白血病患者 细胞免疫 中医辨证分型 |
| 英文关键词:minimal residual leukemia cellular immunity TCM Syndrome typing |
| 基金项目: |
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| 中文摘要: |
| 目的 :分析微小残留白血病 (MRL)患者细胞免疫功能与中医辨证分型的相关性。方法 :用三标记荧光抗体和流式细胞仪测定MRL患者 30例、健康人 5 5名及急性白血病患者 36例的细胞免疫功能 ,比较分析其细胞免疫功能和中医辨证分型相关关系。结果 :MRL患者与健康人比较 ,各项指标普遍降低 ,包括WBC总数、总T淋巴细胞绝对值、辅助T淋巴细胞绝对值 (P <0 0 5 )、淋巴细胞总数、自然杀伤 (NK)细胞百分率和绝对值 (P <0 0 1) ;总T淋巴细胞百分率、CD4 + CD2 9+ 细胞百分率、抑制T淋巴细胞百分率、记忆T淋巴细胞百分率增高 (P <0 0 5或P <0 0 1) ,但绝对值不升高。MRL患者与急性白血病患者比较差异无显著性。MRL患者气血不足型免疫功能紊乱严重 ,包括辅助T淋巴细胞和抑制T淋巴细胞比值较正常降低等。气血不足型免疫功能紊乱最明显 ,气阴两虚型患者紊乱相对较轻 ,阴虚火旺者介于二者之间。结论 :MRL患者免疫功能低下 ,属中医正虚邪恋。不同中医证型细胞免疫紊乱程度不同 ,对不同证型采用不同药物与剂量是有必要的。 |
| 英文摘要: |
| Objective:To analyse the correlation between the cellular immunity and TCM Syndrome typing of patients with minimal residual leukemia (MRI). Methods:The analysis was performed by detecting cellular immunological parameters in 30 MRI patients, 55 bealthy persons and 36 patients with acute leukemia (AL) using three fluoresceine-conjugated monoclonal antibodies and flow cytometer. Results:As compared with those in the healthy persons, universal reductions of various parameters were shown in the MRI patients, including WBC count, absolute value of total T-lymphocytes, T-helper lymphocyte (P<0.05) and total lymphocytes; the percentage and absolute value of NK cells (P<0.01); and the percentages of total T-lymphocytes, CD 4+ CD 29+, T-suppressor cells and T-memory cells (P<0.05 or P<0.01), but without any rising of absolute value. As compared with those in the patients with AL, parameters were similar in the two groups with insignificant difference. The disturbances, including the lowering on ratio of T-helper/T-suppressor lymphocytes, in MRI patients of Qi-blood insufficiency type was the severest, that in the patients of Qi-Yin deficiency type was the mildest, and that in patients of Yin-deficiency with excess Fire type located between them. Conclusion:The immune function of MRI patients is low, belonging to the TCM Syndrome of vital energy deficiency with evil-lingering. Since the degree of cellular immune disturbance is different in various TCM Syndrome types, therefore, they should be treated with different dosages of different drugs. |
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