| 戴令娟,侯杰,蔡后荣.中药和中西药结合治疗肺纤维化的实验研究[J].,2004,(2):130-132 |
| 中药和中西药结合治疗肺纤维化的实验研究 |
| Experimental Study on Treatment of Pulmonary Fibrosis by Chinese Drugs and Integrative Chinese and Western Medicine |
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| DOI： |
| 中文关键词: 肺纤维化 丹参 黄芪 |
| 英文关键词:pulmonary fibrosis Radix Salvia miltiorrhizae Radix Astragalus membranaceus |
| 基金项目:国家自然科学基金资助课题(No.39270870) |
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| 中文摘要: |
| 目的:比较中药丹参、黄芪、雷公藤及西药氢化考的松、硫唑嘌呤及硫唑嘌呤加雷公藤对肺纤维化的作用。方法:将80只SD大鼠分为8组。10只作为正常对照组,70只形成博莱霉素肺纤维化模型;其中10只作为模型对照组,其余60只均分为6组,于灌注博莱霉素第15天开始分别使用丹参、黄芪、雷公藤、氢化考的松、硫唑嘌呤、硫唑嘌呤加雷公藤治疗,持续14天后处死动物,取肺组织作病理切片,进行光镜组织病理学评价及电子计算机图像定量分析,客观评价疗效。结果:丹参疗效居首位,氢化考的松次之,黄芪居第3位。硫唑嘌呤有一定疗效,硫唑嘌呤联合雷公藤治疗后大鼠肺纤维化加重。结论:丹参治疗肺纤维化有肯定的疗效。 |
| 英文摘要: |
| Objective: To compare the effects of treatment of pulmonary fibrosis ( PF) by the Chinese herbal medicines, Radix Salviae miltiorrhizae (Cl ) , Radix Astragalus membranaceus (C2) and Caulis Tripterygium wilfordii (C3 ) ; western drugs, hydrocortisone (W1) and azathioprine (W2 ) , and combined W2 with C3. Methods: Eighty SD rats were divided into 8 groups. Except the 10 rats in the normal control group, the other 70 rats were made into animal model of PF by bleomycin administration, and treated with various medicines, except the 10 rats in the model control group. The treatment started from the 15th day of modeling, the model animals were perfused with C1, C2, C3, W1 , W2 and W2 + C3 respectively for 14 days. Rats were sacrificed by the end of experiment, their lung tissue was taken for pathological section to conduct the pathological examination under light microscope and computerized image quantitative analysis to evaluate the effects of the treatments objectively. Results: The therapeutic effect of C1 was the best, that of W1 the second and C2 the third. W2 showed some effect, but PF worsened after the combined therapy of W2 and C3 was applied. Conclusion: Radix Salviae miltiorrhizae shows definite therapeutic effect in treating PF. |
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