| 冯学功,刘茂才,孙景波,区勇全,邓时贵,欧润妹.益溶口服液对脑梗塞大鼠溶栓状态下再灌注损伤的影响[J].,2004,(2):143-146 |
| 益溶口服液对脑梗塞大鼠溶栓状态下再灌注损伤的影响 |
| Effect of Yirong Oral Liquid on the Reperfusion Injury in Rats with Cerebral Infarction Undergoing Thrombolysis |
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| DOI： |
| 中文关键词: 脑梗塞 溶栓治疗 再灌注并发症 益溶口服液 |
| 英文关键词:cerebral infarction thrombolysis complications of reperfusion Yirong oral liquid |
| 基金项目: |
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| 中文摘要: |
| 目的:观察益溶口服液对脑缺血大鼠溶栓状态下再灌注损伤的影响。方法:采用可逆性局灶性脑缺血大鼠模型与溶栓法相结合,模拟临床溶栓状态下形成再灌注,在此基础上观察益溶口服液对抗氧化能力、脑水肿、脑组织超微结构等指标的影响。结果:益溶口服液可减轻再灌注后脑组织水肿,明显提高大鼠血浆超氧化物歧化酶(SOD)活性、降低丙二醛(MDA)含量,抑制脑缺血再灌注后脂质过氧化反应,明显减轻脑缺血再灌注大鼠脑组织神经细胞的损伤。结论:益溶口服液具有一定的脑保护作用。 |
| 英文摘要: |
| Objective: To observe the effect of Yirong Oral Liquid (YROL) on reperfusion injury in rats with cerebral infarction undergoing thrombolysis. Methods: Clinical reperfusion under thrombolysis was simulated by applying thrombolysis on reversible local cerebral ischemic rat model. In the rat model, effect of YROL on parameters concerning anti-oxidation capability, cerebral edema and ultrastructure of brain were observed. Results: YROL could alleviate the cerebral edema after reperfusion, markedly increase the activity of superoxide dismutase in blood plasma, decrease the content of malonyldialdehyde, inhibit the post-reperfusion lipid peroxidation, and significantly reduce the ischemia/reperfusion injury of nerve cells in brain of rat. Conclusion: YROL has definite protecting effect on brain. |
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