| 张清媛,赵文辉,来玉娟,康欣梅.平消胶囊联合内分泌药物治疗或化疗对晚期乳腺癌的影响[J].,2005,(12):1074-1076 |
| 平消胶囊联合内分泌药物治疗或化疗对晚期乳腺癌的影响 |
| Effect on Late-stage Mammary Cancer Treated by Endocrinotherapy or Chemotherapy Combined with Pingxiao Capsule |
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| DOI： |
| 中文关键词: 平消胶囊 内分泌药物治疗 化疗 乳腺癌 |
| 英文关键词:Pingxiao Capsule endocrinotherapy chemotherapy mammary cancer |
| 基金项目: |
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| 中文摘要: |
| 目的探讨平消胶囊在晚期乳腺癌治疗中的价值和作用。方法142例患者采用随机对照方法,分为单纯内分泌药物治疗组(简称内分泌组)27例、内分泌药物加平消胶囊组(简称内分泌结合组)27例;单纯化疗组(简称化疗组)44例、化疗加平消胶囊组(简称化疗结合组)44例,分别比较单纯内分泌药物或化疗治疗组与联合平消胶囊治疗组的缓解率、疾病进展时间、生存期、生活质量及不良反应。结果联合组较单纯组中位疾病进展时间明显延长(P<0.05)、生活质量提高(P<0.05);联合组和单纯组在缓解率及不良反应方面差异无显著性。结论平消胶囊能提高晚期乳腺癌患者的生活质量,延长疾病进展时间,与化疗或内分泌药物共同用于治疗晚期转移性乳腺癌值得临床推广。 |
| 英文摘要: |
| Objective To explore the action of Pingxiao Capsules (PXC) and its significance in the treatment of late stage mammary cancer (LSMC). Methods One hundred and forty-two LSMC patients were randomized into four groups: the two single treated groups treated by endocrinotherapy (ET) alone (n=27) and by chemotherapy alone(n=44) respectively, and the two PXC combined treated groups treated with PXC plus endocrinotherapy(n=27) or chemotherapy(n=44). The remission rate and progression time (TTP) of disease, the survival time and quality of life (QOL) of patients, and the adverse reaction were compared between the single treated groups and the combined treated groups. Results The median progression time was obviously prolonged, and QOL improved in the combined treated groups than those in the single treated groups(P<0.05), but no significant difference was found in the remission rate or adverse reaction between them. Conclusion PXC can improve QOL, prolong the progression time in patients of LSMC, and with less adverse reaction. It is worth spreading combination of PXC with chemo- or endocrino-therapy in clinical application for treatment of LSMC patients. |
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