| 何羿婷,查青林,阎小萍,苏励,宋跃进,曾升平,刘维,冯兴华,钱先,朱婉华,林色奇,吕诚,吕爱平.类风湿性关节炎症状因子分析及其与疗效的关系[J].,2005,(12):1077-1081 |
| 类风湿性关节炎症状因子分析及其与疗效的关系 |
| Analysis on Symptomatic Factors of Rheumatoid Arthritis and Its Correlation with Therapeutic Efficacy |
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| DOI： |
| 中文关键词: 因子分析 症状 疗效 类风湿性关节炎 |
| 英文关键词:factor analysis symptoms therapeutic efficacy rheumatoid arthritis |
| 基金项目:国家自然科学基金重大计划重点项目(No.90209002);国家十五攻关计划(No.2001BA701A17);国家自然科学基金项目(No.3042121);上海高校中医内科E研究院项目(No.E03008) |
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| 中文摘要: |
| 目的对类风湿性关节炎(rheumatoidarthritis,RA)症状进行因子分析,并探讨其结果与中西药治疗疗效的关系。方法413例确诊为活动期RA病例来自9个临床中心,采用各中心控制的简单随机化方法分成中药组(209例)和西药组(204例)。西药治疗方案包括非甾体抗炎药和慢作用药,中药治疗包括基础治疗和辨证用药。治疗前后收集患者18项常见症状。治疗效果用美国风湿病学会20%改善标准(theAmericanCollegeofRheumatology20%improvement,ACR20)判断。应用SAS8.2软件对数据进行分析。症状的分类用因子分析法分析,各公因子得分变化与疗效关系用方差分析。结果18项症状因子分析得到4个公因子,较好地反映关节局部病情以及中医寒证、虚证、热证的症状;中、西药治疗对反映关节病情的公因子影响一致,均具有改善作用,但中药治疗对虚证症状的公因子改善优于西药组。结论因子分析能够对中医辨证过程中重要因素症状进行分类研究,因子分析结果与传统证候分类有一致性;对公因子与疗效关系的探索,能更好地显示中药疗效的特点。 |
| 英文摘要: |
| Objective To analyze the symptomatic factors of rheumatoid arthritis (RA), and to explore the correlations between these factors and the efficacy of TCM herbal and western medicinal therapies. Methods Four hundred and thirteen patients with confirmed diagnosis as active RA came from 9 clinical centers were randomly divided into the Western medicine (WM) treated group (n=204) and the traditional herbal medicine (CM) treated group (n=209). The scheme of WM therapy included administration of voltaren extended action tablet, methotrexate and sulfasalazine. That of CM therapy included basic treatment and medication by syndrome differentiation. Eighteen items of often seen symptoms of the patients were collected before and after treatment. The therapeutic effect was evaluated by the American College of Rheumatology 20% improvement (ACR 20)and all data were analyzed using SAS 8.2 statistical software package. The category of symptoms was analyzed by factor analysis. The correlation of changes of various common factors with the therapeutic efficacy were analyzed by one- way ANOVA test. Results Four common factors were obtained from the 18 items of symptoms, which could better reflect respectively the local status of arthritis, and symptoms of Cold-syndrome, Asthenia-syndrome and Heat-syndrome in traditional Chinese medicine (TCM). Both CM and WM therapies showed consistent effect on the common factors that reflects the state of RA, but CM therapy showed superior effect on the common factors to improve Asthenia-syndrome to that of WM therapy. Conclusion Factor analysis could be used to categorize and study the important factor symptoms in the syndrome differentiation of TCM, and the results of factor analysis were in accord with the category of TCM syndrome differentiation. The exploration on the correlation of common factor and therapeutic efficacy could better exhibit the characteristics of TCM efficacy. |
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