| 李旋珠,熊洪艳,林青.强胰降糖胶囊对糖尿病模型大鼠的影响[J].,2005,(12):1109-1111 |
| 强胰降糖胶囊对糖尿病模型大鼠的影响 |
| Effect of Qiangyi Jiangtang Capsules on Diabetes Mellitus Model Rats |
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| DOI： |
| 中文关键词: 强胰降糖胶囊 糖尿病 代谢综合征 中医药防治 |
| 英文关键词:Qiangyi Jiangtang Capsules diabetes mellitus metabolic syndrome prevention and therapy by traditional Chinese medicine |
| 基金项目:云南省自然科学基金资助项目(No.2000C0064M) |
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| 中文摘要: |
| 目的研究强胰降糖胶囊对高脂饲料与链脲佐菌素诱导的大鼠糖尿病模型的药效作用,为临床用药提供科学依据。方法以高脂饲料喂饲Wistar大鼠1个月后,禁食18h,腹腔注射0.6%链脲佐菌素30mg/kg,空白组注射等体积柠檬酸缓冲液。5天后断尾取血测全血糖,以血糖高于10.0mmol/L者为造模成功。将造模成功的大鼠随机分为模型组、阳性对照组和受试药(强胰降糖胶囊)高、中、低剂量组。受试药高、中、低剂量组分别按2.0g/kg、1.2g/kg、0.4g/kg的剂量灌胃给予强胰降糖胶囊,空白组和模型组给予等体积生理盐水,阳性对照组按0.5g/kg灌胃给予二甲双胍。给药1个月后测定血糖(bloodglucose,BG)、血清果糖胺(serumfructoseamine,SFA)和糖化血红蛋白(hemoglobinA1c,HbA1c),第2周和第4周测定饮水量和进食量。结果受试药高、中、低3个剂量组BG、SFA、HbA1c;第2周和第4周的饮水量、进食量各指标均明显低于模型组(P<0.05或P<0.01)。结论强胰降糖胶囊能显著降低该动物模型的BG、HbA1c、SFA、饮水量和进食量,是具有进一步开发、研制前景的中药复方制剂。 |
| 英文摘要: |
| Objective To study the pharmacodynamics of Qiangyi Jiangtang Capsules (QJC) to offer the scientific foundation for clinical treatment to model rats of diabetes millitus induced by high lipid forage and streptozotocin. Methods The model rats of diabetes mellitus were induced by intraperitoneal injection of 0.6% streptozotocin (30mg/kg body weight) given to Wistar rats after feeding with high lipid forage for a month and followed by fasting for 18 hours. Rats with level of blood glucose over 10.0 mmol/L 5 days after modelling was regarded as the successful model. Besides, a group of blank control was set up with rats fed with general forage and injected with equal volume of citric acid buffer solution. The successfully modelled rats were randomly divided into the model group, the positive control group and the high (2.0 g/kg), middle (1.2 g/kg) and low (0.4 g/kg) dose QJC treated groups. Meanwhile, the same volume of normal saline was given to rats in the blank control group and the model group, while Matfarmin (0.5 g/kg) was given to the rats in the positive control group. The levels of blood glucose (BG), serum fructose amine (SFA), hemoglobin A1c (HbA1c) were measured after one month of medication, and the amount of water drinking and food intake were measured at the second and the fourth week of the treatment. Results The levels of BG, SFA, HbA1c, the amount of water drinking and food intake in the 3 QJC treated groups were obviously lower than those in the model group(P<0.05 or P<0.01). Conclusion QJC could remarkably lower the levels of BG, HbA1c, SFA and the amount of food intake and water-drinking of DM model rats, it is a Chinese herbal preparation worthy of further development and research. |
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