| 徐培元,赵高贤,常连胜,乔保平.冬凌草液热疗预防浅表性膀胱癌术后复发的非随机同期对照研究[J].,2005,(12):1115-1117 |
| 冬凌草液热疗预防浅表性膀胱癌术后复发的非随机同期对照研究 |
| Local Thermotherapy with Rabdosia Liquid as Prophylactic Measure for Recurrence of Superficial Urinary Bladder Carcinoma: A Non-randomized Contemporary Controlled Study |
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| DOI： |
| 中文关键词: 膀胱癌 浅表性 冬凌草 热疗 复发 |
| 英文关键词:urinary bladder carcinoma superficial rabdosiae rubescens thermotherapy recurrence |
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| 中文摘要: |
| 目的比较中药冬凌草液热疗和多次丝裂霉素膀胱内灌注预防浅表性膀胱移行细胞癌术后复发的作用。方法采用前瞻性非随机同期对照试验,将123例患者分为两组,A组在术后1～2个月开始行冬凌草液热疗,每3个月1次,共1年;B组行丝裂霉素膀胱内多次灌注,术后2周开始,每周1次,共6次,然后每个月1次,共1年。观察术后复发率和无瘤间期及不良反应发生情况。结果随访10～45个月,平均(28.6±5.8)个月。A组复发率5.0%,B组复发率14.3%,两组复发率及KaplanMeier生存曲线比较,差异均有显著性(P<0.05)。治疗后发生膀胱炎、血尿、膀胱挛缩、尿道狭窄A组分别为28.3%、5.0%、1.7%、1.7%,B组分别为25.4%、4.8%、0%、0%,两组比较差异无显著性(P>0.05)。结论冬凌草液热疗对预防浅表性膀胱移行细胞癌术后复发的效果可靠。 |
| 英文摘要: |
| Objective To compare the actions of local thermotherapy with rabdosia liquid and repeated perfusion of mitomycin C for the postoperative prophylaxis of superficial urinary bladder carcinoma. Methods In the prospective non-randomized contemporary controlled study, 123 patients were divided into 2 groups. The patients in group A received local thermotherapy with rabdosia liquid starting from 1-2 months after operation, once tri-monthly for one year. Those in group B received intravesical perfusion of mitomycin C, starting from 2 weeks after operation, once weekly, six times in total, thereafter once monthly for one year. The recurrence rate, disease free interval, and adverse reaction after operation were observed. Results The follow-up lasted for 10—45 months with the average of 28.6±5.8 months. The recurrence rates in group A and B were 5.0% and 14.3%, respectively. Significant difference was shown when compared by Kaplan-Meier analysis of disease free interval and the recurrence rate between the two groups (P<0.05). The occurrence rates of cystitis, hematuria, vesical contracture, urethral stricture were 28.3%, 5.0%, 1.7%, 1.7%, respectively in group A, 25.4%, 4.8%, 0%, 0%, respectively in group B, showing no significant difference between the two groups (P>0.05). Conclusion The effect of local thermotherapy with rabdosia liquid is reliable in preventing the recurrence of superficial urinary bladder transitional cell carcinoma. |
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