| 连方,刘海萍,王云霞,张建伟,孙振高,马凤梅,张宁,刘延荷,孟茜.祛瘀解毒法治疗瘀毒型子宫内膜异位症的机理探讨[J].,2006,(2):110-113 |
| 祛瘀解毒法治疗瘀毒型子宫内膜异位症的机理探讨 |
| Study on Mechanism of Quyujiedu Method in Treating Endometriosis of Stasis-toxic Syndrome Type |
| |
| DOI： |
| 中文关键词: 子宫内膜异位症 祛瘀解毒法 瘀毒 细胞凋亡 |
| 英文关键词:endometriosis Quyujiedu stasis-toxin cell apoptosis |
| 基金项目:山东省医药卫生科研项目1999(No.42) |
|
| Hits: 1530 |
| Download times: 2 |
| 中文摘要: |
| 目的探讨祛瘀解毒法治疗子宫内膜异位症的机理。方法临床研究:60例患者随机分治疗组(用祛瘀解毒方治疗)和对照组(为丹那唑治疗),观察治疗3个月前后症状、体征、妊娠率及白细胞介素1(IL1)、IL6及血清抗子宫内膜抗体(EMAb)的变化。实验研究:60只大鼠分为治疗组(用祛瘀解毒方)、对照组(用丹那唑)与空白组,建立大鼠子宫内膜异位症模型,观察异位内膜腺上皮、在位内膜腺上皮及子宫肌层组织学评分。结果临床研究表明:治疗后痛经积分治疗组和对照组分别为2.40±1.85和3.47±2.03;月经不调积分分别为1.67±2.04和3.73±1.72(P<0.05),两组妊娠率分别为63.2%和23.5%(P<0.05)。中药与丹那唑治疗后均显著降低IL1、IL6含量和EMAb的阳性率。实验研究表明中药与丹那唑均可增加异位内膜腺上皮、在位内膜腺上皮及子宫肌层组织学评分,说明可促进异位病灶细胞的Bax的表达;但中药对在位内膜及肌层组织无此作用。结论祛瘀解毒法可有效改善子宫内膜异位症血瘀蕴毒症候,其作用机理与调节机体免疫状态,促进异位病灶细胞凋亡有关。提示祛瘀解毒方是治疗血瘀蕴毒型子宫内膜异位症的有效方药。 |
| 英文摘要: |
| Objective To observe the mechanism of Quyujiedu (QYJD, a method for removing stasis and detoxicating) in treating endometriosis of stasis-toxic syndrome type. Methods Clinical study: Sixty patients were randomly divided into two groups, the treated group treated with QYJD and the control group treated with Danazol. The changes of clinical symptoms,physical signs, pregnancy rate, as well as levels of interleukin-1 (IL-1), interleukin-6 (IL-6) and endometrial antibody (EMAb) in them before and after treatment were observed. Experimental study: Sixty rats were established into endometriosis model, and randomly divided into the QYJD treated group, the Danazol treated group for positive control and the untreated group for negative control to observe the expression of Bax. Results Clinical study showed that in the treated group and the control group, after treatment, dysmenorrhea score were 2.40±1.85 and 3.47±2.03, the menoxenia score 1.67±2.04 and 3.73±1.72 (P<0.05), and the pregnancy rate 63.2% and 23.5% respectively, the difference between them was significant (all P<0.05). Both of the two treatments can rectify immunity, reduce levels of IL-1 and IL-6, and lower the positive rate of EMAb. Experimental study showed that QYJD could improve the expression of Bax in ectopic endometrium, but could not affect the on-side expression of Bax in endometrium and muscle tissue. Conclusion QYJD is effective in improving the stasis-toxic syndrome of endometriosis, its mechanism related with the regulation of the immune condition and the promotion of cell apoptosis in ectopic endometrium, indicating that QYJD is an effective remedy for endometriosis of stasis-toxic syndrome type. |
| View Full Text View/Add Comment Download reader |
|
|
|
