| 方雪玲,方强,骆建军.生大黄对脓毒症患者血浆D-乳酸及前降钙素表达的影响[J].,2006,(2):128-130 |
| 生大黄对脓毒症患者血浆D-乳酸及前降钙素表达的影响 |
| Effects of Raw Rhubarb on Plasma D-lactate and Procalcitonin Expressions in Patients with Sepsis |
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| DOI： |
| 中文关键词: 生大黄 脓毒症 D-乳酸 前降钙素 |
| 英文关键词:raw rhubarb sepsis D-lactate procalcitonin |
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| 中文摘要: |
| 目的观察生大黄对脓毒症患者血浆D乳酸和前降钙素的影响。方法前瞻、随机抽取符合入选条件的脓毒症患者40例,分为治疗组(18例)和对照组(22例)。治疗组给予生大黄9g/d,对照组给予常规治疗,于治疗前和治疗后测定患者血浆D乳酸和前降钙素水平。结果治疗前治疗组患者的血浆D乳酸水平(mmol/L)0.18±0.05和前降钙素水平(μg/L)6.50±2.37,与对照组(0.19±0.06、6.98±2.89)比较,差异无显著性(P>0.05);治疗后治疗组血浆D乳酸水平0.09±0.03和前降钙素水平2.21±0.61较对照组(0.24±0.06、4.11±1.40)明显下降(P<0.05)。结论生大黄能改善脓毒症患者肠道黏膜通透性,减少肠道细菌移位,减轻脓毒症。 |
| 英文摘要: |
| Objective To investigate the effects of raw rhubarb (RR) on levels of plasma D-lactate and procalcitonin in patients with sepsis. Methods Forty patients with sepsis enrolled were randomly divided into two groups, the RR group (n=18, treated with RR 9 g/d) and the control group (n=22, treated with conventional treatment). Plasma procalcitonin and D-lactate were determined before and after treatment. Results Before treatment, there was no significant difference in the levels of plasma procalcitonin and D-lactate between the two groups (procalcitonin: 6.50±2.37 μg/L vs 6.98±2.89 μg/L; D-lactate: 0.18±0.05 mmol/L vs 0.19±0.06 mmol/L, P>0.05). However, after treatment, two indexes in the RR group were significantly lower than those in the control group (procalcitonin: 4.11±1.40 μg/L vs 2.21±0.61 μg/L; D-lactate: 0.24±0.06ng/L vs 0.09±0.03ng/L, both P<0.05). Conclusion RR could ameliorate the intestinal permeability and reduce the shifting of intestinal bacteria, so as to ease the condition of disease in patients with sepsis. |
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