| 邓云坤,韦方,安邦权,向道康,张大国.银杏叶提取物金纳多对心内直视手术期间心肌损伤标志物的影响[J].,2006,(4):316-318 |
| 银杏叶提取物金纳多对心内直视手术期间心肌损伤标志物的影响 |
| Effects of Ginaton on the Markers of Myocardial Injury during Cardiopulmonary Bypass |
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| DOI： |
| 中文关键词: 银杏叶提取物 心肌损伤标志物 心内直视手术 体外循环 |
| 英文关键词:Ginkgo biloba leaf extract myocardial injury marker cardiopulmonary bypass extracorporeal circulation |
| 基金项目:贵州省优秀科技教育人才专项资金项目(No.200534);贵州省中医药管理局资助项目(No.20041) |
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| 中文摘要: |
| 目的探讨银杏叶提取物金纳多对心内直视手术期间心肌损伤标志物的影响。方法40例先天性心脏病单纯房间隔缺损或室间隔缺损修补术患者,按随机数字表法随机分为银杏组和对照组,每组20例。两组均采用4℃StThomas’停搏液主动脉根部灌注,银杏组在此基础上加入银杏叶提取物金纳多(0.5mg/kg);两组均于心脏完全停跳后开始心内手术。手术前、术后即刻、术后6、12、24、48h取中心静脉血,采用免疫比浊法测定血清C反应蛋白(CRP),采用ELISA法检测肌酸激酶同功酶(CKMB)、肌钙蛋白T(cTnT)和肌钙蛋白I(cTnI)浓度的变化。结果术前两组间CRP、CKMB、cTnT、cTnI浓度比较,差异无显著性(P>0.05),两组患者血清CRP、CKMB、cTnT、cTnI浓度在术后即刻显著升高(P<0.05),对照组于术后12h达峰值,术后48h降至术前水平,同一时点比较,银杏组明显低于对照组(P<0.05,P<0.01)。结论银杏叶提取物金纳多应用于心内直视手术中可显著降低心肌损伤标志物升高程度,促进术后心功能恢复,具有良好的心肌保护效果。 |
| 英文摘要: |
| ObjectiveTo evaluate the effects of Ginaton (Ginkgo biloba leaf extract) on themyocardial injury markers (MIMs) during cardiopulmonary bypass (CPB). Methods Forty patients with congenital heart diseases, scheduled to take atrial septum or ventricular septum repairing operation, were randomly divided into the Ginaton group and the control group, 20 cases in each group. Patients in both groups received St. Thomas’ cardioplegic perfusion via radix aortae, while Ginaton (0.5mg/kg) was added into the perfusion for the Ginton group. Cardiac surgery were started after complete heart arrest. Central venous blood was obtained before and at 0, 6th, 12th, 24th and 48th hour after operation for detection of serum C reaction protein (CRP) by immuno-turbidimetry, as well as creation kinase-MB isoenzyme (CK-MB), cardiac troponin T (cTnT) and cardiac troponin I (cTnI) with enzyme-linked immunosorbent assay (ELISA). Results There was no difference in serum concentration of CRP, CK-MB, cTnT and cTnI between the two groups before operation (P>0.05). These indexes increased immediately after operation in both groups (P<0.05). They reached the peak value 12 hrs after CPB and reduced to normal level 48 hrs post-operation in the control group, with the value significantly higher than that in the Ginaton group at all the corresponding time points (P<0.05, or P<0.01). ConclusionPerfusion with Ginaton during CPB could significantly decrease the release of MIMs and improve post-CPB cardiac function recovery, exerting favorable myocardium-protective effects. |
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