| 赵永新,刘云.来氟米特与白芍总甙治疗类风湿关节炎的临床观察[J].,2006,(4):355-357 |
| 来氟米特与白芍总甙治疗类风湿关节炎的临床观察 |
| Clinical Observation on Effects of Leflunomid and Total Glucosides of Paeony on Rheumatoid Arthritis |
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| DOI： |
| 中文关键词: 类风湿关节炎 白芍总甙 来氟米特 |
| 英文关键词:rheumatoid arthritis total glucosides of Paeony leflunomide |
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| 中文摘要: |
| 目的观察来氟米特(LEF)与白芍总甙(TGP)治疗类风湿关节炎(RA)的临床疗效及实验室指标的变化。方法80例患者随机分为两组,LEF加TGP治疗组40例;单用LEF对照组40例,疗程12周。观察患者治疗前后临床疗效、症状、体征及实验室各项指标的变化情况。结果治疗组总有效率为97.5%,对照组总有效率为85.0%,两组比较,差异有显著性(P<0.05),治疗组临床指标和实验室指标较治疗前有显著改善(P<0.05,P<0.01),且优于对照组(P<0.05,P<0.01)。不良反应两组总体比较,差异无显著性。结论LEF加TGP联合治疗类风湿关节炎起效快,不良反应少,优于单独使用LEF。 |
| 英文摘要: |
| ObjectiveThe observe the clinical effect of leflunomide (LEF) and total glucosides of Paeony (TGP) on rheumatoid arthritis (RA) and their influences on laboratory findings. MethodsEighty patients with RA were randomly divided into 2 groups, 40 in each group: the treated group treated with TGP and leflunomide, and the control group treated with LEF alone, the therapeutic course for both groups was 12 weeks. Clinical effect after treatment, changes of symptoms and physical signs before and after treatment were observed and the relative laboratory indexes were detected as well. Results The total effective rate in the treated group was higher than that in the control group (97.5% vs 85.0%, P<0.05). The clinical and laboratory indexes in the treated group were improved significantly after treatment (P<0.05, P<0.01), with the improvement superior to those in the control group (P<0.05, P<0.01) respectively. There was no significant difference in adverse reaction between the two groups. ConclusionCombined application of TGP and LEF is superior to using of LEF alone in treating RA, owing to its quicker initiating action and less adverse reaction. |
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