| 潘云苓,潘远志.志苓胶囊治疗中晚期肺癌的疗效观察[J].,2006,(7):604-607 |
| 志苓胶囊治疗中晚期肺癌的疗效观察 |
| Observation on the Effect of Zhiling Capsule in Treating Patients with Lung Cancer of Middle/Advanced Stage |
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| DOI： |
| 中文关键词: 志苓胶囊 中晚期肺癌 气阴两虚 安全性 |
| 英文关键词:Zhiling Capsule lung cancer of middle/ advanced stage deficiency of both qi-yin safety |
| 基金项目:福建省科技计划资助项目(No.2001Z053) |
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| 中文摘要: |
| 目的观察志苓胶囊治疗中晚期肺癌的疗效和安全性。方法采用多中心随机、双盲、平衡对照方法,分别用志苓胶囊(全方组104例)、志苓胶囊的西药成分(拆方1组52例)、中药成分(拆方2组46例)和平消胶囊(对照组48例)口服2周,观察各组治疗前后中医证侯(气阴两虚)改变及临床症状、生活质量、体重增减情况和毒副反应。结果全方组、拆方1组、拆方2组和对照组中医证候(气阴两虚)改善率分别为91·3%、80·8%、37·0%、14·6%;胸闷胸痛缓解率分别为86·9%、60·5%、20·0%、10·0%;纳食不香改善率分别为80·4%、47·9%、23·7%、10·3%;生活质量治疗后全方组和两拆方组比治疗前显著提高(P<0·05或(P<0·01),且全方组提高幅度优于其他3组(P<0·01);体重治疗后全方组显著增加,且增加程度优于其他3组(P<0·05)。4组均未见明显不良反应。结论志苓胶囊能明显缓解中晚期肺癌患者中医证候和改善生存质量。 |
| 英文摘要: |
| ObjectiveTo observe the effect and safety o f Zhiling Capsule (ZC) in treating lung cancer of middle/advanced stage. Methods With the multi-center, r andomized, double-blinded and parallel controlled method, the patients were div i ded into 4 groups, the 104 patients in the group A were treated with the whole r ecipe of ZC, the 52 in the group B with the disassembled recipe 1 (Western medic ines) of ZC, the 46 in the group C with the disassembled recipe 2 (Chinese medic ines) of ZC, and the 48 in the control group with Pingxiao Capsule, all the drug s were administered orally for 2 weeks. The changes of syndrome of qi-yin defi c iency, symptoms, quality of life (QOL), body weight and adverse reactions occurr ed in patients were observed. ResultsThe effective rate in alleviating syndrom e in the groups A-D was 91.3%, 80.8%, 37.0% and 14.6% respectively; in remi tting stuffiness and chest pain 86.9%, 60.5%, 20.0% and 10.0%; in improving appe tite was 80.4%、47.9%、23.7% and 10.3%. QOL in the groups A-C was signific antly elevated after treatment (P<0.05 or P<0 .01), the improvement of group A was superior to that of other treatments ( P<0.01). Body weight in the group A was significantly increased an d superior to that of others (P<0.05). The whole recipe of ZC showed the therapeutic effect superior to that of the other treatments (P<0.05). No obvious adverse reaction was found in all the 4 groups. ConclusionZC can improve the symptoms and QOL in patien ts with lung cancer of middle/advanced stage. |
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