| 于大君,聂莉芳,许勇钢,杨晓红,孙红颖,欧阳晃平.益气滋肾颗粒对IgA肾病辅助性T淋巴细胞亚群的影响[J].,2006,(9):836-838 |
| 益气滋肾颗粒对IgA肾病辅助性T淋巴细胞亚群的影响 |
| Regulatory Effects of Yiqi Zishen Granule on Helper T-Lymphocyte Subsets in IgA Nephropathy Patients |
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| DOI： |
| 中文关键词: 益气滋肾颗粒 IgA肾病 辅助性T淋巴细胞亚群 |
| 英文关键词:Yiqi Zishen Granule IgA nephropathy helper T lymphocyte subsets |
| 基金项目:国家科技部基础性工作专项资金项目分课题(No.2001DEA20010) |
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| 中文摘要: |
| 目的进一步阐明IgA肾病的发病机制及益气滋肾颗粒对IgA肾病辅助性T淋巴细胞亚群(Th1/Th2)的影响。方法应用流式细胞仪分别检测31例服用益气滋肾颗粒治疗3个月前后的IgA肾病患者(治疗组)和24名健康对照组的Th1/Th2细胞内细胞因子。结果与健康对照组比较,治疗组γ-干扰素(IFN-γ)百分比降低(P<0·05),白介素-4(IL-4)、白介素-10(IL-10)百分比升高(P<0·01)。治疗组治疗后与治疗前比较,IFN-γ百分比升高(P<0·05),IL-10百分比降低(P<0·01)。结论IgA肾病患者存在Th1/Th2的失衡,益气滋肾颗粒对IgA肾病Th1/Th2的失衡有一定调节作用。 |
| 英文摘要: |
| ObjectiveTo study the pathogenesis of IgA nephropathy (IgAN) and the effect of Yiqi Zishen Granule (YZG) on the helper T-lymphocyte subsets Th1/Th2 in IgAN patients. MethodsIntracellular cytokines secreted by Th1/Th2 were measured using flow cytometry in 24 healthy subjects and 31 IgAN patients treated by YZG before and after treatment. ResultsLevel of interferon-γ (IFN-γ) was lower (P<0.05) and levels of interleukin 4 (IL-4) and interleukin 10 (IL-10) were higher (P<0.01) in the IgAN patients than those in the healthy controls, showing imbalance of Th1/Th2 in the IgAN patients. After YZG treatment, the level of IFN-γ increased and IL-10 level decreased (P<0.01). ConclusionImbalance of Th1/Th2 exists in IgAN patients. YZG has a regulatory effect on imbalance of Th1/Th2 in IgAN patients. |
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