| 胡国华,党西强,王井和,姚静婵,王有成.肾病合剂配合激素对小儿复发性肾病的临床疗效及血、尿IL-6和TNF-α影响的研究[J].,2006,(10):892-895 |
| 肾病合剂配合激素对小儿复发性肾病的临床疗效及血、尿IL-6和TNF-α影响的研究 |
| Clinical Effect of Shenbing Mistura Combined with Glucocorticoid on Recurrent Nephrotic Syndrome in Children and Levels of Interleukin-6 and Tumor Necrosis Factor-α in Blood and Urine |
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| DOI： |
| 中文关键词: 复发性肾病综合征 肾病合剂 白细胞介素-6 肿瘤坏死因子-α 糖皮质激素 |
| 英文关键词:recurrent nephrotic syndrome Shenbing Mistura interleukin-6 tumor necrosis factor-alpha glucocorticoid |
| 基金项目:浙江省金华市科技局自然科技基金资助项目(No.2003-1-333) |
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| 中文摘要: |
| 目的探讨中药肾病合剂配合激素对小儿复发性肾病(RNS)的临床疗效及血、尿白细胞介素-6(IL-6)和肿瘤坏死因子-α(TNF-α)的影响。方法将患者分为治疗组、对照组,并设健康组,各30例,治疗组采用肾病合剂配合激素治疗,对照组单纯用激素治疗;观察治疗前及治疗后4、8、12周血、尿中的IL-6和TNF-α浓度以及临床疗效和复发情况。结果血、尿IL-6和TNF-α含量治疗前后自身对照及两组间比较,差异均有显著性(P<0.01)。两组临床疗效比较差异有显著性(P<0.01)。随访18个月,治疗组复发率明显低于对照组(P<0.01)。结论肾病合剂配合激素能够减少小儿肾病复发,提高临床疗效,降低血、尿IL-6和TNF-α的水平。 |
| 英文摘要: |
| Objective To study the effect of Shenbing Mistura(SM)combined with glucocorticoid on recurrent nephrotic syndrome(RNS)in children and levels of interleukin-6(IL-6)and tumor necrosis factor-α(TNF-α)in blood and urine.Methods The treatment group was treated with SM plus glucocorticoid,the control group with glucocorticoid alone,and a healthy control group was adopted,30 cases in each group.The clinical effect and recurrence rate were observed,and levels of IL-6 and TNF-α in blood and urine were determined before treatment and at the 4th,8th,12th week after treatment.Results Significant difference of IL-6 and TNF-α levels in blood and urine was found in either the pre-and post-treatment auto-control of both the treatment group and control group,or in the inter-group comparison of them(P<0.01);clinical effect also showed remarkable difference between the two groups(P<0.01).Furthermore,the recurrence rate of the treatment group was lower than that of the control group showed by a 18-month follow-up(P<0.01).Conclusion SM combined with glucocorticoid could significantly reduce the recurrence rate and elevate the clinical effect in children with RNS,it could also lower the levels of IL-6 and TNF-α in patients’ blood and urine. |
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