| 黄晶,黄永生.复律保心口服液对急性心肌梗死大鼠抗脂质过氧化及其对血浆一氧化氮及血管内皮生长因子的影响[J].,2006,(10):926-929 |
| 复律保心口服液对急性心肌梗死大鼠抗脂质过氧化及其对血浆一氧化氮及血管内皮生长因子的影响 |
| Effect of Fulu Baoxin Oral Liquid on Lipid Peroxidation,Plasma Nitric Oxide and Vascular Endothelial Growth Factor in Acute Myocardial Infarction Rats |
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| DOI： |
| 中文关键词: 复律保心口服液 急性心肌梗死 抗脂质过氧化 |
| 英文关键词:Fulu Baoxin Oral Liquid acute myocardial infarction anti-lipid peroxidation |
| 基金项目:国家“八五”科技攻关课题(No.85-919-02-2) |
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| 中文摘要: |
| 目的通过观察复律保心口服液(复律保心)对急性心肌梗死大鼠抗脂质过氧化作用,及其对血浆一氧化氮(nitric oxide,NO)及心肌组织内血管内皮生长因子(vascular endothelial growthfactor,VEGF)含量的影响,进一步探讨其防治急性心肌梗死(AMI)的作用机制。方法检测各组实验大鼠心肌组织中超氧化物歧化酶(SOD)及丙二醛(MDA)含量,同时检测各组实验大鼠血浆NO含量,并采用免疫组织化学法检测各组AMI大鼠心肌组织中VEGF的含量。结果复律保心高剂量组、阳性对照组SOD浓度均明显高于急性心肌梗死模型组(P<0.01),复律保心高剂量组、阳性对照组MDA浓度均明显低于急性心肌梗死模型组(P<0.01);复律保心高剂量组、阳性对照组大鼠血浆NO含量及心肌组织中VEGF的含量与AMI模型组比较,差异有显著性(P<0.05)。结论复律保心口服液能使急性心肌梗死大鼠SOD活力明显升高,使脂质过氧化产物MDA含量明显降低;复律保心口服液具有明显的上调AMI实验大鼠血浆NO及心肌组织VEGF含量的作用,说明其对急性心肌梗死的治疗作用可能与其抗脂质过氧化,减少自由基损伤同时上调血浆NO水平及心肌组织VEGF的含量,促进冠脉侧枝循环建立有关。 |
| 英文摘要: |
| Objective To study the effect and mechanism of Fulu Baoxin Oral Liquid(FBOL)on lipid peroxidation(LPO),plasma nitric oxide(NO)and vascular endothelial growth factor(VEGF)in myocadial tissue of rats with acute myocardial infarction(AMI).Methods The contents of superoxide dismutase(SOD),malondialdehyde(MDA)and VEGF in myocardial tissue and the plasm NO level were determined by immunohistochemical method.Results Compared with those in AMI model rats,contents of SOD,plasma NO and myocardial VEGF were higher and MDA was lower obviously in the FBOL high dosage and coronary favorable medicine treated rats(P<0.05 or P<0.01).Conclusion FBOL could increase SOD activity and lower MDA content in myocardial tissue,and up-regulate plasma NO and myocardial VEGF,which may be related to its curative effect on AMI. |
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