| 宋坪,颜志芳,许铣,刘瓦利.复方莪倍软膏治疗斑块状银屑病的临床观察[J].,2007,(4):352-354 |
| 复方莪倍软膏治疗斑块状银屑病的临床观察 |
| Clinical Observation on Effect of Compound E-Bei Ointment in Treating Plaque Psoriasis |
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| DOI： |
| 中文关键词: 复方莪倍软膏 斑块状银屑病 疗效评价 |
| 英文关键词:compound E-Bei Ointment plaque psoriasis efficacy evaluation |
| 基金项目:国家中医药管理局青年基金资助项目(No00-01LQ16) |
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| 中文摘要: |
| 目的观察复方莪倍软膏对于斑块状银屑病的治疗作用及安全性。方法采用区组随机、开放、阳性西药及安慰剂平行对照的方法。将120例入选患者在口服扫癣丸情况下,分别采用复方莪倍软膏、达力士软膏、软膏基质外涂治疗4周,疗程结束后评价红斑、浸润、鳞屑、瘙痒的改善情况及皮损面积改变情况及安全性,并观察症状改善时间。结果局部症状改善情况:中药组和西药组红斑、鳞屑、浸润、瘙痒程度治疗前后评分比较,差异有显著性(P<0.01),而安慰剂组仅鳞屑评分差异有显著性(P<0.01);治疗后两治疗组与安慰剂组比较,差异均有显著性(P<0.01)。中药组瘙痒症状改善时间少于西药组及安慰剂组,差异有显著性(P<0.01),而其他症状改善时间差异无显著性;中药组及西药组的红斑、鳞屑、浸润症状改善时间均少于安慰剂组,差异有显著性(P=0.01);中药组与西药组不良事件发生比较差异无显著性;而中药组复发相对少于西药组。结论复方莪倍软膏能够有效改善斑块状银屑病的皮损症状,其疗效不低于阳性西药。 |
| 英文摘要: |
| Objective To observe the efficacy and safety of Compound E-Bei Ointment (CEBO) in treating plaque psoriasis. Methods Adopting block-randomized, open, positive Western medicine and placebo parallel group controlled method, a total of 120 enrolled patients were administered orally with Saoxuan Pill, and randomized into three groups respectively treated with external application of CEBO, Daivonex, or vehicle control twice a day for 4 weeks. The changes of erythema, infiltration, scaly eruption, pruritus and the area of lesion were evaluated, the safety and the initiating time of symptom improvement (ITSI) were observed as well. Results Observation on local lesion showed that the scores of erythema, infiltration, scaly eruption, pruritus were significantly improved in difference between the CEBO group and the Daivonex group (P<0.01). But in the placebo control group, significant improvement was only shown in scaly eruption scores (P<0.01), so, the improvement in skin lesion in the placebo group was significantly inferior to that in the other two groups (P<0.01). The ITSI of pruritus was shorter in CEBO group than that in the Daivonex group and the placebo group (P<0.01), but that of other symptoms showed insignificant difference between the CEBO group and the Daivonex group, as for comparing in ITSI of erythema, infiltration, scaly eruption and pruritus, it was significantly shorter in the CEBO group and Daivonex group than that in the placebo group respectively(P<0.01). The occurrence of adverse events in the CEBO group had insignificant difference to that in the Daivonex group, but the recurrence rate in the former was significantly lower than that in the latter (P<0.05). Conclusion CEBO can effectively improve the symptoms of skin lesion in patients with plaque psoriasis, the clinical efficacy is not inferior to that of positive Western medicine. |
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