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Author Name	Affiliation
LIU Run-hong	复旦大学华山医院中西医结合研究所 (上海200040)
ZHANG Xin-min	复旦大学华山医院中西医结合研究所 (上海200040)
ZHANG Su-qin	复旦大学华山医院中西医结合研究所 (上海200040)
顾一峰	复旦大学华山医院中西医结合研究所 (上海200040)
蔡外娇	复旦大学华山医院中西医结合研究所 (上海200040)
陈伟华	复旦大学华山医院中西医结合研究所 (上海200040)
应健	复旦大学华山医院中西医结合研究所 (上海200040)

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中文摘要:

目的探索中药复方别敏对变应性鼻炎干预作用机制。方法采用卵清蛋白(OVA)腹腔注射造成变应性鼻炎小鼠模型,观察小鼠行为学变化、脾脏淋巴细胞增殖能力及血清总IgE和OVA特异性IgE含量的变化。结果中药复方别敏能明显减少变应性鼻炎模型小鼠的抓鼻和喷嚏数;抑制植物血凝素A和OVA刺激引起的脾脏淋巴细胞增殖;降低血清总IgE和OVA特异性IgE含量。结论中药复方别敏具有抑制脾脏淋巴细胞增殖,降低血清IgE等作用。

英文摘要:

Objective To investigate the effect and mechanism of Biminne,a Chinese herbal compound preparation,for treatment of allergic rhinitis(AR).Methods AR model of mouse was induced by intraperitoneal injection of ovalbumin(OVA),and the changes in behavior,proliferative activity of splenic lymphocyte,serum levels of total IgE and OVA specific IgE were observed.Results Biminne showed effects in reducing the frequency of sneezing and nasal rubbing,inhibiting the proliferation of splenic lymphocyte stimulated by phytohemagglutinin(PHA)and OVA,and lowering the levels of serum total IgE and OVA specific IgE.Conclusion Biminne could inhibit the proliferation of splenic lymphocyte and reduce serum level of IgE in mice with AR.

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