| 卢晓男,徐向荣,林丽君.抗异种玉汤联合GnRH-a治疗重度子宫内膜异位症不孕患者疗效观察[J].,2007,(11):980-982 |
| 抗异种玉汤联合GnRH-a治疗重度子宫内膜异位症不孕患者疗效观察 |
| Clinical Observation on Treatment of Infertile Patients with Severe Endometriosis by Kangyi Zhongyu Decoction Combined with Gonadotropin Releasing Hormone-a |
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| 中文关键词: 抗异种玉汤 促性腺激素释放激素 子宫内膜异位症 不孕 体外受精-胚胎移植术 |
| 英文关键词:Kangyi Zhongyu Decoction gonadotropin releasing hormone-a endometriosis infertile in vitro fertilization and embryo transfer |
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| 中文摘要: |
| 目的探讨抗异种玉汤联合促性腺激素释放激素(GnRH-a)激动剂治疗重度子宫内膜异位症不孕患者的临床疗效。方法经腹腔镜确诊后拟行体外受精-胚胎移植(IVF-ET)术的75例患者随机分为3组,每组25例,分别用抗异种玉汤联合GnRH-a(联合组)、单纯抗异种玉汤(中药组)和单纯GnRH-a(西药组)治疗,用药3个月后进行IVF-ET术,观察3组疗效及不良反应,并检测治疗前后血清癌胚抗原125(CA125)和抗子宫内膜抗体(EMAb)的变化。结果联合组和中药组治疗后性交痛评分明显低于西药组(P<0.01)。联合组妊娠率〔56%(14/25例)〕高于中药组〔28%(7/25例)〕和西药组〔32%(8/25例)〕(P<0.05),且不良反应小于西药组(P<0.01)。治疗后联合组EMAb阳性率〔20%(5/25例)〕低于中药组〔48%(12/25例)〕和西药组〔52%(13/25例)〕(P<0.05)。结论抗异种玉汤联合GnRH-a治疗重度子宫内膜异位症不孕患者可提高辅助生育技术成功率,是一种疗效理想、不良反应小的新方法。 |
| 英文摘要: |
| Objective To observe the therapeutic effect of Kangyi Zhongyu Decoction (KZD) combined with gonadotropin releasing hormone-a (GnRH-a) on infertile patients with severe endometriosis. Methods Seventy-five infertile patients with the diagnosis of endometriosis confirmed by laparoscope who were scheduled to receive in vitro fertilization and embryo transfer (IVF-ET) were randomly assigned to three groups, they were treated respectively with KZD (A), GnRH-a (B) alone and combined of both (C), and IVF-ET were applied in the patients after 3 months of treatment. The clinical efficacy and adverse reactions in the three groups were observed and the changes of serum cancer antigen 125 (CA125) and endometrial antibody (EMAb) levels before and after treatment were tested. Results Score of dyspareunia in Group A and C was obvioushy lower than that in Group B after treatment (P<0.01). Pregnancy rate in Group C was higher than that in Group A and B (P<0.05), with the adverse reactions less than in Group B (P<0.01). The positive rate of plasma EMAb was reduced obviously after treatment in Group C with the level lower than that in the other two groups (P<0.05). Conclusion The combined use of KZD and GnRH-a is a new method in treating infertile patients with severe endometriosis with ideal effectiveness and fewer adverse reactions, and it could advance the successful rate of reproductive assistant technique. |
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