| 祁天寿,李国庆,徐贵江,费伟.自拟消抗种子方治疗抗精子抗体阳性男性不育的临床观察[J].,2007,(11):983-985 |
| 自拟消抗种子方治疗抗精子抗体阳性男性不育的临床观察 |
| Clinical Observation on Treatment of Male Infertility with Positive Antisperm Antibody by Self-formulated Xiaokang Zhongzi Recipe |
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| DOI： |
| 中文关键词: 自拟消抗种子方 抗精子抗体阳性 男性不育 |
| 英文关键词:self-formulated Xiaokang Zhongzi Recipe positive antisperm antibody male infertility |
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| 中文摘要: |
| 目的观察自拟消抗种子方治疗抗精子抗体阳性男性不育的疗效。方法将110例血清抗精子抗体阳性患者按数字表法随机分为两组(各55例),分别用消抗种子方(治疗组)和泼尼松(对照组)治疗3个月,并观察临床疗效和药物不良反应。结果治疗组痊愈38例(69.1%),有效14例(25.4%),无效3例(5.5%,其中退出2例);对照组痊愈12例(21.8%),有效11例(20.0%),无效32例(58.2%,其中退出4例、未转阴20例、复阳8例)。治疗组和对照组抗精子抗体转阴率分别为94.5%(52/55例)、41.8%(23/55例),转阴时间分别为(45±14)天、(62±21)天;两组临床疗效与抗精子抗体转阴率和平均转阴时间比较差异均有统计学意义(P<0.01)。治疗组3例(5.5%)、对照组8例(14.5%)出现药物不良反应。结论消抗种子方治疗抗精子抗体阳性男性不育疗效优于泼尼松,药物不良反应少而轻微。 |
| 英文摘要: |
| Objective To observe the therapeutic effect of self-formulated Xiaokang Zhongzi Recipe (XZR) in treating male infertility with positive antisperm antibody (AsAb). Methods One hundred and ten male infertility patients with positive AsAb were randomly assigned, according to randomized digital table, to the trial group treated with XZR, and the control group, treated with prednisone, 55 in each group. Clinical therapeutic effect and adverse reactions of the drugs were observed after 3 months of treatment. Results In the trial group after treatment, 38 patients (69.1%) were cured, 14 (25.4%) improved and 3 treated in vain (5.5%, including 2 dropped out). While in the control group, the corresponding numbers were 12 (21.8%), 11 (20.0%) and 32 (58.2%,including 4 dropped out, 20 remained AsAb positive and 8 with AsAb reverted to positive after negative conversion). The negative conversion rate and average negative conversion time in the trial group and the control group were respectively 94.5%, (45±14) days and 41.8%, (62±21) days. Significant difference between the two groups was shown in therapeutic effectiveness and average negative conversion time (P<0.01). Adverse reactions occurred in 3 cases (5.5%) in the trial group and 8 (14.5%) in the control group. Conclusion XZR is better than prednisone in treating male infertility with positive AsAb, and with fewer and milder adverse reactions. |
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