| 周开,龚文波,周建扬,陈霞波,贺娟,陈民利,王晖.降浊合剂对MSG肥胖大鼠糖脂代谢的影响[J].,2008,(11):1014-1017 |
| 降浊合剂对MSG肥胖大鼠糖脂代谢的影响 |
| Influence of Jiangzhuo Mixture on Glucose and Lipid Metabolism in MSG Obese-induced Rats |
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| DOI： |
| 中文关键词: 降浊合剂 罗格列酮 游离脂肪酸 MSG肥胖大鼠 |
| 英文关键词:Jiangzhuo Mixture rosiglitazone free fatty acid MSG-inducedobese rat |
| 基金项目:浙江省中医药管理局基金资助项目(No.2002C104);2006年获浙江省中医药科技进步三等奖 |
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| 中文摘要: |
| 目的观察比较降浊合剂对MSG(L-谷氨酸钠)肥胖大鼠糖脂代谢、胰岛素敏感指数(ISI)及游离脂肪酸(FFA)等指标的影响。方法8～10周龄的雄性MSG大鼠64只,随机分成罗格列酮组、降浊合剂高剂量组(高剂量组)、降浊合剂低剂量组(低剂量组)、模型对照组,每组各16只,降浊合剂高、低剂量组每天分别以降浊合剂浓缩液20mL/kg、10mL/kg灌胃,罗格列酮组按每天20mg/kg(10mL)予罗格列酮水溶液灌胃,模型对照组以蒸馏水10mL/kg灌胃,连续给药7周。观察给药前后空腹血糖(FBG)、甘油三酯(TG)、胆固醇(TC)及血清空腹胰岛素(Ins),给药后各组FFA、脂肪/体重,并计算ISI。结果经过药物干预7周后,高剂量组、低剂量组、罗格列酮组的TC、FBG、Ins、脂肪/体重、FFA水平均明显低于同期模型对照组,其中给药后TC显著低于同组给药前,FBG、Ins显著高于同组给药前水平,给药后罗格列酮组Ins则显著低于同期高剂量组和低剂量组,ISI显著高于同期模型对照组;高剂量组、低剂量组、罗格列酮组给药后ISI均较同组给药前均显著降低(P<0.05),高剂量组、低剂量组与同期模型对照组ISI比较差异无统计学意义(P>0.05)。给药后FFA高剂量组〔(314.81±110.25)μmol/L〕、罗格列酮组〔(305.56±92.33)μmol/L〕均显著低于同期低剂量组〔(375.00±219.95)μmol/L〕(P<0.05)。结论降浊合剂能显著降低MSG大鼠血清TC、FBG、Ins、FFA水平,其降低FFA的作用存在剂量依赖性,但对成长期MSG大鼠ISI的影响不明显,不能逆转MSG大鼠的高血糖、高胰岛素血症及胰岛素抵抗的形成过程。 |
| 英文摘要: |
| Objective To study the effect of Jiangzhuo Mixture(JZM)on glucose and lipid metabolism,free fatty acid(FFA)and insulin sensitivity index of sodium glutamate(MSG)induced obese rats.Methods Sixty-four male MSG rats,8-10 weeks old,were randomly divided into 4 groups equally,the low dose and high dose JZM group were treated respectively with 10 mL/(kg·d)and 20 mL/(kg·d)JZM,the rosiglitazone(RGZ)group with water solution of RGE 20 mg/(kg·d),while the model group fed only with distilled water 10 mL/(kg·d)for control,all by gastrogavage for 7 successive weeks.Levels of fasting blood glucose(FBG),triglyceride(TG),cholesterol(TC),and serum fasting insulin(Ins)were measured before and after treatment.Besides,the level of FFA and the proportion of fat weight to body weight(F/B)were measured and insulin sensitivity index(ISI)was calculated after treatment.Results After being treated for 7 weeks,the indexes including TC,FBG,Ins,F/B and FFA were all lower than those in the model group.Compared with before treatment,TC level lowered,FBG and Ins level raised in the two JZM groups and the RGZ group.Comparisons between the three treated group showed a significant lower level of Ins in the RGZ group.Level of ISI was significantly lowered in the 3 groups after treatment(P<0.05),but still higher in the RGZ group than that in the model control group(P<0.05).As for level of FFA,it was 314.81±110.25 μmol/L in the high dose JZM group and 305.56±92.33μmol/L in the RGZ group,which were lower than that in the low dose JZM group(375.00±219.95 μmol/L,P<0.05).Conclusions JZM could decrease the serum levels of TC,FBG,Ins and FFA in MSG rats,and decrease the fat content of organism in rats’ growth process.The FFA decreasing action is dose-dependent.But its effect on ISI in MSG rats in the growth stage is insignificant.JZM can not reverse the forming processes of hyperglycemia,hyperinsulinemia,and insulin resistance in MSG rats. |
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