| 黄光照,李玲,刘良,韦登明.雷公藤中毒的尸检病理变化——附4例尸检报告[J].,2009,(2):165-168 |
| 雷公藤中毒的尸检病理变化——附4例尸检报告 |
| Pathological Study on Autopsy Died of Tripterygium Intoxication——Report of 4 Cases |
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| DOI： |
| 中文关键词: 雷公藤 中毒 尸检 病理变化 |
| 英文关键词:Tripterygium poisoning autopsy pathological change |
| 基金项目: |
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| 中文摘要: |
| 中药雷公藤制剂已广泛用于治疗类风湿关节炎、红斑性狼疮等多种自身免疫性疾病,并已取得明显疗效而引起关注。但本品具有一定毒性,其有效治疗量与最小中毒量比较接近。为提供临床安全用药参考,本研究报告了4例因雷公藤中毒的尸检病理报告。其中2例是因心脏损害引起心源性休克死亡,其心肌细胞可见水变性、甚至心乳头肌收缩带坏死明显;2例因重度急性中毒性肾病死于急性肾功能衰竭;4例均见脑水肿及胃肠炎等病变。提示,用药剂量十分关键;应废弃直接用雷公藤生药治疗疾病,要采用正规药厂生产的雷公藤制剂,以预防今后类似中毒死亡案例的发生。 |
| 英文摘要: |
| The Tripterygium preparation,a Chinese herbal medicine,has been widely used to treat various autoimmune diseases,such as rheumatoid arthritis and systemic lupus erythematosus.Its significant clinical effects have received a great praise and attention by the public health in China,but its toxicity also definitely exists,with the therapeutic dosage approaching the minimal toxic dosage.In order to provide reference for the safe use of Tripterygium preparation in clinical practice,the pathological changes of 4 autopsy cases by Tripteryqium poisoning were reported in this paper.In them,2 cases died of acute cardiogenic shock caused by myocardial damage,showing hydropic degeneration of the myocardial cells,even with obvious contraction band necrosis in the papillary muscles;the other 2 died of severe acute renal failure due to severe acute toxic nephrosis;cerebral edema and gastrointestinal inflammatory changes were found in all cases.The authors suggested that careful dosage control is the key step to prevent Tripterygium intoxication during the medical treatments;directly using the crude Tripterygium in clinics should be prohibited;and the Tripterygium preparation used should be produced by the pharmaceutical companies regulated by the government. |
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