| 沈自尹,黄建华,林伟,王琦,吴斌,刘小雨,张新民,许世雄,张卫东.从整体论到系统生物学进行肾虚和衰老的研究[J].,2009,(6):548-550 |
| 从整体论到系统生物学进行肾虚和衰老的研究 |
| Transition of Studying on Shen Deficiency Syndrome and Aging from Holistic Concept to Systematic Biologic Viewpoint |
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| DOI： |
| 中文关键词: 整体观 中医学 肾阳虚 系统生物学 衰老 |
| 英文关键词:holistic concept Chinese medicine Shen yang deficiency syndrome systematic biology aging |
| 基金项目:国家重点基础研究计划973项目(No.2007CB507400);国家自然科学基金项目(No.904090010);上海市卫生局中医药科研基金项目(No.2004J014A) |
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| 中文摘要: |
| 中医学对世界医学的贡献之一就是整体观,我们从整体观出发研究了肾阳虚证与下丘脑-垂体-靶腺轴功能紊乱的联系;采用基因芯片技术研究老年大鼠(肾虚证)及中药干预后下丘脑-垂体-肾上腺-胸腺(HPAT)轴的分子网络调控规律;通过基因芯片也揭示存在于老年大鼠下丘脑、垂体、肾上腺、淋巴细胞、骨骼、肝脏、肾脏等与"肾"相关组织的神经-内分泌-免疫以及神经-内分泌-骨代谢两大基因网络路线,从而推进"证"的整体性研究。近年按照系统生物学的动态、干预、多层面整合的要求,在全基因组转录水平、代谢组和单个衰老相关信号通路3个不同层面揭示衰老在不同层面的共同规律;揭示出基因的时空关联随着衰老进程逐渐弱化;并且中药淫羊藿总黄酮能有效改善衰老在上述两方面的系统改变。因此从整体观到系统生物学的转变可能促进中医学进入现代生命科学领域。 |
| 英文摘要: |
| Holistic concept is a characteristic contribution of Chinese medicine to medical science. Based on holistic concept,we investigated the correlation of Shen yang deficiency syndrome with the hypothalamus-pituitary-target gland axis;and revealed by gene chip technique the molecular network regulatory rule of intervention with Chinese drugs on hypothalamus-pituitary-adrenal-thymus axis in aged rats as a model for Shen deficiency syndrome;also the two major gene regulation pathways,namely,the neuro-endocrine-immune pathway and the neuro-endocrine-bone metabolic pathway,in hypothalamus,pituitary,adrenal,lymphocytes,kidney,liver,bone of aged rats,so as to advance the holistic research on Chinese medicine syndromes. Recently,based on the dynamic,intervention and multi-layer integration requirement of systematic biology,the common rule of aging was found at three different levels,the whole genomic transcription level,the metabolic level and the single ageing signaling pathway level. Meanwhile,it was demonstrated that the temporal and spatial association of genes will be weakened gradually along with aging. And Epimedium Flavonoids (EF),an extracts from Epimedium have been proved to be capable of effectively reversing both of these systemic changes. Thus,the transition of study from holistic concept to systematic biologic viewpoint could surely promote the progression of Chinese medicine to modern life science. |
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