| 李晓昊,邓伟民,张金玉,周丽,黄伟毅.补肾壮骨冲剂对围绝经期妇女性激素及血脂代谢的影响[J].,2009,(7):599-602 |
| 补肾壮骨冲剂对围绝经期妇女性激素及血脂代谢的影响 |
| Effect of Bushen Zhuanggu Granule on the Gonadal Hormone and Blood Lipids Metabolism in Climacteric Women |
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| DOI： |
| 中文关键词: 围绝经期 性激素 血脂 一氧化氮 氧自由基 |
| 英文关键词:climacteric women gonadal hormone blood lipid nitric oxide free oxygen radical |
| 基金项目:广东省中医药管理局资助课题(No.2060124,N0.102151) |
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| 中文摘要: |
| 目的观察补肾壮骨冲剂对围绝经期妇女性激素、血脂及血清一氧化氮(NO)、氧自由基的影响。方法采用随机数字表法将就诊的围绝经期妇女分为中药组(188例)及西药组(189例)。中药组口服补肾壮骨冲剂治疗2年,西药组应用倍美力加安宫黄体酮治疗2年。主要观察患者的症状疗效及治疗前后血脂[总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)]、性激素[雌二醇(E2)、卵泡刺激素(FSH)、促黄体生成素(LH)]、NO、超氧化物歧化酶(SOD)、丙二醛(MDA)水平的变化情况。结果(1)病例脱落情况:中药组治疗2年后脱落53例,西药组脱落96例,两组比较差异有统计学意义(P<0.01)。(2)疗效:中药组显效率36.30%(49/135),有效率82.96%(112/135);西药组显效率30.11%(28/93),有效率73.12%(68/93),两组比较,中药组疗效优于对照组(P<0.05)。(3)两组治疗后症状总评分均明显减少(P<0.05,P<0.01),且中药组的作用更明显(P<0.01)。(4)性激素和血脂比较:两组治疗后与治疗前比较均明显改善(P<0.05);治疗后组间比较,在升高E2方面,西药组优于中药组(P<0.05)。(5)两组治疗1年和2年的血清NO、SOD水平升高、MDA水平降低(P<0.05,P<0.01)。两组治疗后比较,差异均无统计学意义(P>0.05)。(6)不良反应:每6个月复查1次血、尿、便常规、肝、肾功能及心电图,无明显不良反应出现。结论补肾壮骨冲剂能有效改善围绝经期妇女症状,纠正紊乱的血脂、性激素、NO及SOD等指标,不良反应较少,疗效与雌激素替代疗法相当。 |
| 英文摘要: |
| Objective To investigate the effect of Bushen Zhuanggu Granule(BZG)on the gonadal hormone,blood lipids,serum level of nitric oxide(NO)and free oxygen radical(FOR)in climacteric women.Methods Climacteric women were randomized according the digital table into the CM group(188 cases)and the WM group(189 cases).They were treated by BZG and Premarin plus Depogeston respectively for 2 years.The therapeutic effect on patients’ symptoms and changes of blood lipids,gonadal hormones,NO,superoxide dismutase(SOD)and malonaldehyde(MDA)were observed.Results There were 53 women in the CM group and 96 in the WM group dropping out in the 2-year follow-up period,the difference between them was significant(P<0.01).The obvious and effective rates in the CM group were 36.30%(49/135),82.96%(112/135),and in WM were 30.11%(28/93),73.12%(68/93),the difference between the two group was significant(P<0.05).The score of complaint was significantly lower in both groups(P<0.05,P<0.01),and the effect was more obvious in the CM group(P<0.01).Effects on gonadal hormones and blood lipids were significantly improved in both groups after treatment(P<0.05);comparison between groups showed the superiority of WM in increasing estrogen(P<0.05),Blood levels of NO and SOD increased and MDA decreased in both groups after 1-and 2-year treatment(P<0.05 or P<0.01),showing no significant inter-group difference(P>0.05).No evident adverse reaction was found in the routine tests on blood,urine and stool,hepatic and renal functions and electrocardiogram examined once every 6 months.Conclusion BZG can effectively restore the disordered indices of gonadal hormones,blood lipids,NO,and SOD in climacteric women,with the efficacy equivalent to the effect of hormone replacement therapy,but it is more safe and inexpensive. |
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