| 尤艳利,凌昌全,封颖璐,赵东宝,戴生明,韩星海,施冶青.人参皂苷联合泼尼松治疗系统性红斑狼疮的随机双盲对照研究[J].,2009,(9):776-779 |
| 人参皂苷联合泼尼松治疗系统性红斑狼疮的随机双盲对照研究 |
| Efficacy of Combined Therapy with Ginsenosides and Prednisone in Treating Systemic Lupus Erythematosus——A Randomized,Controlled and Double-blinded Trial |
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| DOI： |
| 中文关键词: 系统性红斑狼疮 人参皂苷 泼尼松 |
| 英文关键词:systemic lupus erythematosus ginsenosides prednisone |
| 基金项目:国家自然科学基金青年基金资助项目(No.30701132);上海市卫生局科研基金资助项目(No.2008JG228) |
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| 中文摘要: |
| 目的探讨人参皂苷联合泼尼松治疗系统性红斑狼疮(systemic lupus erythematosus,SLE)的治疗效果。方法采用随机数字表法将60例SLE患者分为2组,每组30例:治疗组在常规泼尼松治疗基础上给予人参皂苷胶囊每次50 mg,每天2次,对照组在常规泼尼松治疗基础上加安慰剂胶囊每次50 mg,每天2次。观察治疗3个月后SLE患者的临床总体疗效、SLEDAI评分、血沉、补体C3及抗ds-DNA情况。结果治疗组总有效率为83.3%,与对照组60.0%比较,差异有统计学意义(P<0.05),治疗组SLEDAI评分、血沉和补体C3改善情况亦优于对照组,差异有统计学意义(P<0.01,P<0.05)。结论人参皂苷可以提高泼尼松治疗SLE的临床疗效,降低SLEDAI评分,促进血沉、补体C3的恢复。 |
| 英文摘要: |
| Objective To observe the therapeutic efficacy of combined therapy with ginsenosides(GS) and prednisone on systemic lupus erythematosus(SLE).Methods Sixty patients with SLE were assigned to 2 groups randomly by a randomizing digital table,the treated group and the control group,30 cases in each group.All patients were treated with routine administration of prednisone,but to the treated group GS Capsule(50 mg) was given additionally twice every day,while to the control group placebo capsule of equal dosage was given instead.The total clinical efficacy,and changes of systemic lupus erythematosus disease activity index(SLEDAI),erythrocyte sedimentation rate(ESR),complement 3(C3) and anti-ds-DNA were observed after 3-month-treatment.Results The total clinical efficacy rate was 89.28% in the treated group and 66.67% in the control group,showing a significant difference between them(P<0.05).The improvements of SLEDAI,ESR and C3 in the treated group were more significant than those in the control group(P<0.01,P<0.05).Conclusion The combined therapy of GS and prednisone could enhance the clinical efficacy,reduce the SLEDAI and promote the recovery of laboratory indices in SLE patients. |
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