| 吴国琳,范永升,韩咏梅,余国友.养阴解毒活血方对系统性红斑狼疮患者激素撤减和疾病活动程度的影响[J].,2009,(9):780-782 |
| 养阴解毒活血方对系统性红斑狼疮患者激素撤减和疾病活动程度的影响 |
| Effect of Yangyin Jiedu Huoxue Recipe on Hormone Withdrawal and Disease Activity in Patients with Systemic Lupus Erythematosus |
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| 中文关键词: 养阴解毒活血中药 系统性红斑狼疮 激素撤减 疾病活动 骨桥蛋白 |
| 英文关键词:Yangyin Jiedu Huoxue Recipe systemic lupus erythematosus hormone withdrawal activity of disease osteopontin |
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| 中文摘要: |
| 目的观察养阴解毒活血中药对系统性红斑狼疮(SLE)血浆骨桥蛋白(osteopontin,OPN)和活动程度(SLEDAI积分)的影响,探讨其在SLE患者激素撤减中的作用。方法将78例SLE患者按随机数字表法分为中药组(42例,养阴解毒活血中药和西药治疗)和对照组(36例,单纯西药治疗),8周为1个疗程。分别观察两组患者治疗2个疗程前后泼尼松每日剂量、SLEDAI积分以及OPN水平的变化。结果2个疗程结束后中药组泼尼松每日剂量(10.03±4.29)mg,撤减变化优于对照组(15.13±6.67)mg(P<0.05),两组患者SLEDAI积分和OPN水平均较治疗前降低,且中药组[(9.17±4.12)分,(117.69±78.50)μg/L]低于对照组[(11.60±4.05)分,(151.09±83.90)μg/L](P<0.05),所有患者治疗前后SLEDAI积分和OPN水平均呈正相关(治疗前r=0.44,治疗后r=0.39,P<0.05)。结论养阴解毒活血方治疗SLE可以控制疾病的活动性,帮助患者早日撤减泼尼松用量。血浆OPN水平与患者疾病活动程度有关。 |
| 英文摘要: |
| Objective To observe the effect of Yangyin Jiedu Huoxue Recipe(YJHR) on the degree of activity integral of systemic lupus erythematosus(SLEDAI) and plasma osteopontin(OPN),and its effect for hormone withdrawal in patients with systemic lupus erythematosus(SLE).Methods Seventy-eight patients were randomly assigned by a randomizing digital table to two groups,42 patients in the treated group and 36 in the control group,all were treated with conventional Western medical treatment,and YJHR was given additionally to the treated group.Changes of SLEDAI and OPN,as well as the daily dosage of prednisone used were observed after 2 courses of treatment.Results SLEDAI and OPN were lowered in both groups,but the lowering in the treated group [9.17±4.12,(117.69±78.50)μg/L] was more significant than that in the control group [11.60±4.05,(151.09±83.90) μg/L,P<0.05].The two indices were positively correlated.The dosage of prednisone daily used in the treated group(10.03±4.29) was reduced more than that in the control group(15.14±6.67,P<0.05).SLEDAI of all the patients before and after treatment had a positive relationship with OPN respectively(r=0.44,0.39)(P<0.05).Conclusions YJHR can suppress the activity of disease and be helpful for early withdrawal of prednisone in treating SLE.Plasma level of OPN is related with the activity of the disease. |
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