| 李爱民,赵佳.人参健心胶囊对冠心病糖耐量异常患者胰岛素抵抗的影响[J].,2009,(9):830-833 |
| 人参健心胶囊对冠心病糖耐量异常患者胰岛素抵抗的影响 |
| Effect of Renshen Jianxin Capsule for Alleviating Insulin Resistance in Patients with Coronary Heart Disease and Glucose Tolerance Impairment |
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| DOI： |
| 中文关键词: 人参健心胶囊 冠心病 糖耐量异常 胰岛素抵抗 |
| 英文关键词:Renshen Jianxin Capsule coronary heart disease glucose tolerance impairment insulin resistance |
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| 中文摘要: |
| 目的观察人参健心胶囊治疗冠心病合并糖耐量异常患者的临床疗效及对胰岛素抵抗的影响。方法将气虚血瘀型冠心病合并糖耐量异常患者80例,随机分为试验组和对照组,每组40例。在硝酸酯类药物治疗的基础上,试验组口服人参健心胶囊,对照组口服二甲双胍,疗程20周。观察两组患者治疗前后临床症状及空腹血糖(FBG)、胰岛素(INS)、胰岛素敏感指数(ISI)的变化。结果两组治疗后中医证候积分均比治疗前降低,差异有统计学意义(P<0.01,P<0.05);试验组心绞痛治疗显效率47.5%,总有效率80.0%,均高于对照组,差异有统计学意义(P<0.05);治疗后两组FBG、INS、ISI与治疗前比较均有改善,差异有统计学意义(P<0.05,P<0.01);治疗后组间FBG、INS、ISI比较,差异无统计学意义(P>0.05)。结论人参健心胶囊能明显改善胰岛素抵抗状态,此作用可能是其临床治疗冠心病心绞痛的作用机制之一。 |
| 英文摘要: |
| Objective To explore the effect of Renshen Jianxin Capsule(RJC) on insulin resistance in patients with coronary heart disease(CHD) and glucose tolerance impairment(GTI).Methods Eighty patients with CHD-GTI of qi-deficiency blood-stasis syndrome were randomly assigned to 2 groups equally,the treated group was treated by RJC and the control group by metformin,based on the conventional Western medical treatment with nitric esters for 20 weeks.Changes before and after treatment in clinical symptoms and levels of blood glucose insulin,and insulin sensitivity index(ISI) were observed.Results The scores of clinical symptoms of Chinese medicine decreased in both groups,which showed statistical significances compared with those before treatment(P<0.01,P<0.05).On alleviating the angina pectoris,the markedly effective rate of the treated group is 47.5%,the total effective rate was 80.0%,and the difference between the two groups showed statistical significance(P<0.05).FBG,INS and ISI were improved significantly in both groups after treatment(P<0.05,P<0.01);while the three indices showed in significant difference between the two groups after treatment(P>0.05).Conclusion RJC was effective in improving insulin resistant,which may be one of the mechanisms of its therapeutic effect on CHD. |
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