| 吴雄志.运用新一代抗肿瘤药物分类系统指导中医学研究[J].,2009,(9):838-840 |
| 运用新一代抗肿瘤药物分类系统指导中医学研究 |
| Using a New Generation of Classification System of Antineoplastic Drugs to Guide Chinese Medicine Research |
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| DOI： |
| 中文关键词: 肿瘤 增殖 分化 凋亡 |
| 英文关键词:tumor proliferation differentiation apoptosis |
| 基金项目:国家自然科学基金资助项目(No.30801495) |
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| 中文摘要: |
| 在反复比较第一代与第二代抗肿瘤药物分类系统的基础上,提出了第三代抗肿瘤药物分类系统,将抗肿瘤药物分为细胞毒药物、细胞生物行为调节剂、生物应答调节剂与生化调节剂。生物应答调节剂(如免疫调节剂)和生化调节剂(即化疗增效减毒剂)常常是西医肿瘤治疗的补充手段,而中药的细胞毒作用通常明显低于化疗药物,要想在中医肿瘤学研究取得新的突破,就必须采用"新思维、新技术、新靶点",从新的角度研究中药的作用机制。中药逆转肿瘤细胞生物学行为异常可能是中医肿瘤学研究的一个重要突破口。 |
| 英文摘要: |
| A new generation of classification system of antineoplastic drugs was put forward based on comparing the first with the second generation classification system of antineoplastic drugs.Antineoplastic drugs are divided into cytotoxic drug,cells biological behavior regulator,biological response modifier and biochemical modulator.The using of biological response modifier(immune modulator for instance) and biochemical modulator are supplementary methods for Western medicine treatment in tumor,because the cytotoxic effets of Chinese herbs are lower than those of chemotherapeutic drugs.For the new breakthrough of Chinese medicine oncology research,new idea,new technology and new target should be used,the Chinese medicine mechanism should be studied from a new view.Reversing abnormal biological behavior of tumor cells by Chinese medicine could be an important breakthrough of Chinese medicine oncology research. |
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