| 崔晓云,吴旸,农一兵,王轩,郭自强,金刚,宋麦芬,王旭升,林谦.凉血生肌方对冠心病介入术后再狭窄及心血管事件的干预[J].,2010,30(1):30-32 |
| 凉血生肌方对冠心病介入术后再狭窄及心血管事件的干预 |
| Effect of Liangxue Shengji Recipe on Incidence of Post-percutaneous Coronary Intervention Restenosis and Adverse Cardiovascular Events |
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| DOI： |
| 中文关键词: 冠状动脉介入术 再狭窄 心血管事件 凉血生肌方 |
| 英文关键词:coronary intervention restenosis adverse cardiovascular events Liangxue Shengji Recipe |
| 基金项目:国家中医药管理局基金资助项目(No.02-03LP09) |
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| 中文摘要: |
| 目的观察凉血生肌方对冠心病介入术后再狭窄及心血管事件发生的干预作用。方法采用随机、单盲的方法,100例冠心病支架植入患者随机分为常规西药对照组和凉血生肌方治疗组,随访至少6个月后并继续随访,以介入术后再狭窄事件及心源性死亡、急性心肌梗死、复发心绞痛、严重心衰、再介入和冠脉搭桥等不良事件发生率为主要观察指标,观察凉血生肌方对介入术后再狭窄及心血管事件发生的干预作用。结果两组支架内再狭窄、复发心绞痛、估计再狭窄事件的发生率比较,差异无统计学意义(P>0.05),发生估计再狭窄事件的累积风险差异无统计学意义(P>0.05);两组在减少单独心血管事件的发生概率上差异无统计学意义(P>0.05),对于联合心血管事件而言,两组比较差异具有统计学意义(P=0.032),两组患者发生联合心血管事件的累积风险差异具有统计学意义(P=0.036)。结论冠心病介入术后服用凉血生肌方药能降低联合心血管事件发生的概率和累积风险,其益处约在术后6个月显现。 |
| 英文摘要: |
| Objective To observe the intervention effect of Liangxue Shengji Recipe(LSR) on incidence of post-percutaneous coronary intervention(post-PCI) restenosis and adverse cardiovascular events.Methods With a randomized,single-blinded methods adopted,100 patients with coronary artery disease(CHD)and underwent stent implantation were randomized into two groups,the control group and the treated group,conventional Western treatment was administered to them all,but with LSR to patients in the treated group additionally. They were followed up for at least six months.The incidences of post-PCI restenosis and adverse events,including cardiogenic death,acute myocardial infarction,recurrent angina pectoris,severe heart failure,further intervention and coronary artery bypass grafting,were observed to estimate the effect of LSR.Results No statistically significant difference between the two groups was shown in terms of incidences of intra-stent restenosis,recurrent angina pectoris,estimator of restenosis and its cumulative risk,as well as in reducing the incidence of single adverse event,but did show statistically significant difference between groups in reducing the incidence of united cardiovascular event(P = 0.032) and its cumulative risk(P = 0.036).Conclusion Administration of LSR in post-PCI stage could significantly reduce the probability and cumulative risk of united cardiovascular events,and the beneficial effect presents at about six months post-PCl. |
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