| 檀金川,胡金焕,苏敬文.滋肾生血方对肾性贫血长期血液透析患者内源性促红细胞生成素的影响[J].,2010,30(1):42-44 |
| 滋肾生血方对肾性贫血长期血液透析患者内源性促红细胞生成素的影响 |
| Effect of Zishen Shengxue Recipe on Endogenous Erythropoietin in Patients with Renal Anemia Undergoing Long-term Hemodialysis |
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| DOI： |
| 中文关键词: 长期血液透析 肾性贫血 促红细胞生成素 滋肾生血方 |
| 英文关键词:long-term hemodialysis renal anemia erythropoietin Zishen Shengxue Recipe |
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| 中文摘要: |
| 目的通过观察滋肾生血方对长期血液透析患者内源性促红细胞生成素的影响,探讨其治疗肾性贫血的作用机制。方法60例肾性贫血的长期血液透析患者随机分为治疗组30例与对照组30例,分别采用滋肾生血方口服配合重组人类促红细胞生成素(rHuEpo)皮下注射和仅皮下注射rHuEpo治疗,疗程8周,比较两组患者的内源性人红细胞生成素(Epo)、血红蛋白(Hgb)、红细胞压积(Hct)、残余肾功能(RRF)等。结果对照组血清Epo水平较用药前无明显改善(P>0.05),治疗组血清Epo水平较用药前明显升高,与对照组比较,差异有统计学意义(P<0.05)。两组Hgb、Hct均较用药前明显上升(P<0.01),且治疗组高于对照组,差异有统计学意义(P<0.01)。两组RRF较用药前均有所下降,且对照组RRF较治疗组下降明显,差异有统计学意义(P<0.05)。结论滋肾生血方能提高血清Epo、Hgb及Hct水平,延缓长期血液透析患者的残余肾功能的下降,改善患者的肾性贫血状态。其机制可能是在促进内源性Epo分泌的同时,减轻尿毒症毒素对红细胞生成的抑制作用。 |
| 英文摘要: |
| Objective To investigate the mechanism of Zishen Shengxue Recipe(ZSR) in treating renal anemia by observing its effect on serum level of endogenous erythropoietin in patients undergoing long-term hemodialysis. Methods Sixty renal anemia patients undergoing long-term hemodialysis were randomly and equally assigned to two groups.The treated group was treated with subcutaneous injection of erythropoiesis stimulating factor(rHuEpo) combined with oral intake of ZSR,and the control group treated with rHuEpo alone.They were observed for eight weeks,and the blood levels of endogenous human erythropoietin(Epo),hemoglobin(Hgb), hematocrit(Hct),as well as the residual renal function(RRF) in the two groups were compared.Results Serum Epo level in the control group was unchanged after treatment(P>0.05),while that in the treated group increased significantly,and showed significant difference in comparing with that in the control group(P<0.05).Levels of Hgb and Hct increased and RRF decreased in both groups(P<0.01),but the treated group showed higher increments and lesser decrement than those in the control group(P<0.05).Conclusions ZSR can enhance the blood levels of Hgb,Hct and Epo,postpone the descent of RRF,and correct the anemic status in patients.Its mechanism of action is possibly through alleviating the inhibition of uremic toxin on erythropoiesis, in the meanwhile of promoting the secretion of Epo. |
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