| 张燕,郭伶俐,赵士鹏,蔡建辉.参芪扶正注射液联合手术后化疗治疗结直肠癌疗效观察[J].,2010,30(3):280-282 |
| 参芪扶正注射液联合手术后化疗治疗结直肠癌疗效观察 |
| Effect of Shenqi Fuzheng Injection Combined with Chemotherapy in Treating Colorectal Cancer |
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| DOI： |
| 中文关键词: 结直肠癌 CD+4CD+25 调节性T细胞 肿瘤坏死因子-α 白细胞介素-12 参芪扶正注射液 化疗 |
| 英文关键词:colorectal cancer CD+4CD+25 Treg cell tumor necrosis factor-α interleukin-12 Shenqi Fuzheng Injection chemotherapy |
| 基金项目:河北省卫生厅基金资助项目(No.08120) |
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| 中文摘要: |
| 目的探讨参芪扶正注射液辅助化疗的疗效及机制。方法将40例住院结直肠癌患者随机分为两组,每组20例:对照组用FOLFOX方案化疗;试验组在对照组化疗基础上静脉滴注参芪扶正注射液;疗程均5天。检测治疗前后外周血中CD4+CD2+5调节性T细胞(regulatory Tcells,Treg)、肿瘤坏死因子α(TNF-α)及白介素12(IL-12)含量变化。并根据WHO抗癌药物急性及亚急性毒性反应分度标准进行分级统计。结果对照组2例在观察期间脱落。结直肠癌患者CD4+CD2+5细胞含量较健康人明显升高(P<0.05);化疗后CD4+CD2+5细胞含量两组均降低(P<0.05);TNF-α及IL-12试验组化疗后升高(P<0.05),对照组降低(P<0.05);两组3项指标治疗后比较差异有统计学意义(P<0.05)。试验组较对照组化疗毒副反应明显减轻(P<0.05)。结论参芪扶正注射液辅助化疗,可调节机体免疫系统,提高化疗效果,还可减轻化疗药物的毒副反应。 |
| 英文摘要: |
| ObjectiveTo explore the effect and mechanism of Shenqi Fuzheng Injection(SFI) for assisting of chemotherapy in treating colorectal cancer(CRC).MethodsForty CRC patients were randomly and equally assigned to two groups,the control group received chemotherapy of FOLFOX protocol and the test group treated with the same chemotherapy combining with SFI.The CD+4CD+25 regulatory T(Treg) cells,tumor necrosis factor-α(TNF-α) and interleukin-12(IL-12) in peripheral blood were determined before and after treatment,and the toxicity of chemotherapy assessed according to the WHO criteria for acute and subacute toxic reaction of anticancer drugs.ResultsTwo cases in the control group were lost during the observing period.The amount of CD+4CD+25 Treg cells in peripheral blood in CRC patients was significantly higher than the normal range(P<0.05),which was lowered significantly after treatment in both groups(P<0.05).Levels of TNF-α and IL-12 significantly elevated in the test group after treatment but lowered in the control group,showing significant difference between groups(both P<0.05).As compared with the control group,the adverse reaction to the chemotherapy was significantly lessened in the test group(P<0.05).ConclusionUsing SFI for assisting chemotherapy could not only improve the immune function of organism to enhance the effect of chemotherapy,but also reduce the adverse reaction of the chemotherapy. |
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